Quantitative analysis of enzyme-altered foci in rat hepatocarcinogenesis experiments--I. Single agent regimen.
Quantitative analysis of enzyme-altered foci in rat hepatocarcinogenesis experiments--I. Single agent regimen.
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大鼠肝癌实验中酶改变灶的定量分析--I．
DOI：
10.1093/carcin/11.8.1271
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发表时间：
1990
期刊：
影响因子：
4.7
通讯作者：
Schwarz,M
中科院分区：
文献类型：
--
作者：
Moolgavkar,SH;Luebeck,EG;deGunst,M;Port,RE;Schwarz,M
最近相当多的注意力集中在啮齿动物肝癌实验中酶改变灶的定量分析。这些病灶被认为是癌前细胞的克隆。提出了一种用于定量分析这些病灶的方法，该方法考虑到在每个肝脏横截面中观察到的病灶横断的总数和这些横断的尺寸分布。该方法，它有一个自然的解释框架内的两个突变模型的致癌作用，产生估计的启动率和增长率的酶改变病灶的剂量的函数的代理正在考虑中。提出了启动和促进效力的定义。该方法是通过应用到一个实验中，大鼠在其饮用水中给予不同浓度的N-亚硝基吗啉说明。
Considerable recent attention has focused on the quantitative analysis of enzyme-altered foci in rodent hepatocarcinogenesis experiments. These foci are believed to represent clones premalignant cells. A method is presented for the quantitative analysis of these foci that takes into account both the total number of focal transections observed in each liver crosssection and the size distribution of these transections. The method, which has a natural interpretation within the framework of a two-mutation model for carcinogenesis, yields estimates of rates of initiation and of growth rates of enzyme-altered foci as functions of dose of the agent under consideration. Definitions of initiation and promotion potencies are proposed. The method is illustrated by application to an experiment in which rats were administeredN-nitroso morpholine at various concentrations in their drinking water.