Role of autologous bone marrow transplantation as consolidation therapy in acute promyelocytic leukemia patients in complete remission.
Role of autologous bone marrow transplantation as consolidation therapy in acute promyelocytic leukemia patients in complete remission.
复制标题
自体骨髓移植作为巩固治疗在完全缓解的急性早幼粒细胞白血病患者中的作用。
作者：
E. Ottaviani;G. Martinelli;N. Testoni;G. Visani;M. Tani;S. Tura
自体骨髓移植（ABMT）死亡率低，已被提议作为首次完全缓解的急性早幼粒细胞白血病（APL）患者维持化疗的替代方法，无论患者的分子状态如何。16例急性APL完全缓解患者接受ABMT，并通过逆转录-聚合酶链反应（RT-PCR）分析PML-RARa融合基因的存在。我们的研究表明，在接受未净化的ABMT程序的患者中，ABMT前PCR分析的持续阳性可以预测随后的复发。
Autologous bone marrow transplantation (ABMT), which consents a low mortality rate, has been proposed as an alternative approach to maintenance chemotherapy in patients with acute promyelocytic leukemia (APL) in first complete remission irrespective of the patients' molecular status. Sixteen patients with acute APL in complete remission were submitted to ABMT and were analyzed for the presence of the PML-RARa fusion gene by reverse transcription-polymerase chain reaction (RT-PCR). Our study demonstrated that continued positivity of PCR analysis before ABMT could predict subsequent relapse in patients who undergo un-purged ABMT procedures.