Expression of claudins 1, 4, 5, and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue
Expression of claudins 1, 4, 5, and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue
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DOI：
10.1016/j.humpath.2007.12.015
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发表时间：
2008-08-01
期刊：
影响因子：
3.3
通讯作者：
Salo, Tuula
中科院分区：
文献类型：
--
作者：
Bello, Ibrahim O.;Vilen, Suvi-Tuuli;Salo, Tuula
claudin和occludin是已知在正常组织和上皮性肿瘤中起作用的紧密连接蛋白。我们分析了claudin 1、4、5、7和occludin在97例舌鳞癌浅表前部和浸润前部的分布规律，以及它们与病因特异性（舌鳞癌）患者生存（中位随访33.5个月，范围1-234个月）的关系。claudin 1和7强烈表达，claudin 4中等表达，claudin 5表达最少。Occludin染色多为阴性或极弱。对舌癌（HSC-3）细胞的Western blot分析表明，这些蛋白在体外也有表达。在病因特异性生存分析中，与中等免疫反应性相比，claudin 7免疫反应性强和低往往与生存降低有关。我们建议分析claudin7的免疫组织学染色水平可用于舌鳞癌患者的预后。(C) 2008爱思唯尔公司版权所有。
Claudins and occludin are tight junctional proteins known to play a role in normal tissues and epithelial tumors. We analyzed the distribution patterns of claudins 1, 4, 5, and 7 and occludin in the superficial and invasive front of squamous cell carcinoma of the tongue of 97 patients and their relationship to cause-specific (squamous cell carcinoma of the tongue) patient survival (median follow-up period of 33.5 months; range, 1-234 months). Claudins I and 7 were strongly expressed, claudin 4 had moderate expression, whereas claudin 5 was least expressed. Occludin staining was mostly negative or very weak. Western blot analysis of tongue carcinoma (HSC-3) cells showed that all these proteins are also expressed in vitro. In cause-specific survival analysis, strong and low immunoreactivity of claudin 7 tended to be associated with decreased survival compared with medium immunoreactivity. We suggest that analyzing the immunohistologic staining levels of claudin 7 could be used for the prognostic purposes in patients with tongue squamous cell carcinoma. (C) 2008 Elsevier Inc. All rights reserved.