Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans.
Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans.
复制标题
成年人 24 小时随意摄入食物的增加与第二天早上血浆鸢尾素浓度的降低有关。
DOI：
10.1016/j.appet.2015.03.003
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发表时间：
2015
期刊：
影响因子：
5.4
通讯作者：
Thearle,MarieS
中科院分区：
文献类型：
--
作者：
Schlögl,Mathias;Piaggi,Paolo;Votruba,SusanneB;Walter,Mary;Krakoff,Jonathan;Thearle,MarieS
Background:The relationship between food intake and irisin concentrations in humans is unclear.Objectives:To determine whether the previous day's intake impacts fasting plasma irisin concentrations, or whether fasting irisin concentrations associate with subsequentad libitumfood intake.Methods:Sixty-six nondiabetic adults (42 men) were admitted for a study of the determinants of energy intake. After 6 days of a weight maintaining diet,ad libitumenergy intake over 3 days was assessed using a vending machine paradigm. Fasting plasma irisin concentrations were measured on the morning of the second day of the vending period.Results:There were no correlations between irisin and demographic or anthropometric parameters. On day 1, subjects consumed 144 ± 52% of weight maintaining energy needs. Every additional 500 kcal consumed on day 1 associated with a 3.4% lower irisin concentration the following morning (95% CI −6.2, −0.4%, p = 0.01; adjusted for age, sex and race). If energy intake was expressed as a percentage of weight maintaining energy needs, every 10% increase associated with a 1.9% lower irisin concentration (95% CI −3.7, −0.1%; adjusted p = 0.02). A 100 kcal increase in carbohydrate or fat consumption associated with a 1.3% (95% CI −2.5, −0.1%, p = 0.01) and a 0.6% (95% CI −1.1, −0.0%, p = 0.02) lower irisin concentration, respectively. There was no association between fasting irisin concentrations and subsequent energy intake on day 2 (r = 0.19, p = 0.1).Conclusions:Higherad libitum24 h energy intake was associated with lower fasting irisin concentrations the following morning, but fasting irisin concentrations did not predict subsequent energy intake. The decrease in irisin concentrations with increased energy intake is consistent with the detrimental metabolic effects of overeating.
