Auditory temporal processes in normal-hearing individuals and in patients with auditory neuropathy
Auditory temporal processes in normal-hearing individuals and in patients with auditory neuropathy
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DOI：
10.1016/j.clinph.2004.09.027
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发表时间：
2005-03-01
影响因子：
4.7
通讯作者：
Zeng, FG
中科院分区：
文献类型：
--
作者：
Michalewski, HJ;Starr, A;Zeng, FG
目的：采用电生理学和心理声学方法，客观地研究一组听力正常者和一组听力受损的听神经病（AN）患者的听觉时间加工过程。方法：在连续噪声中，用头皮记录的诱发电位测量2 ~ 50 ms的短暂无声间隔（间隙）。结果：正常人在主动和被动两种情况下，对短至5 ms的间隙均能记录到诱发电位（N100/P200成分）。AN受试者的间隙诱发电位仅出现在延长的间隙持续时间（10-50 ms）。有一个密切的关联之间的差距检测阈值测量psychoacoustically和electrophysiologically在正常人和AN subjects.Conclusions：听觉皮层电位可以提供客观措施的auditory temporal processes.Significance：电生理和心理声学的方法相结合的融合，为研究听觉皮层的时间处理在正常人和听力受损的个人提供有用的客观措施。所使用的程序也可以提供客观的时间处理措施，用于评估特殊人群，如儿童谁可能无法提供主观反应。(c)2004年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To study objectively auditory temporal processing in a group of normal hearing subjects and in a group of hearing-impaired individuals with auditory neuropathy (AN) using electrophysiological and psychoacoustic methods.Methods: Scalp recorded evoked potentials were measured to brief silent intervals (gaps) varying between 2 and 50 ms embedded in continuous noise. Latencies and amplitudes of N100 and P200 were measured and analyzed in two conditions: (1) active, when using a button in response to gaps; (2) passive, listening, but not responding.Results: In normal subjects evoked potentials (N100/P200 components) were recorded in response to gaps as short as 5 ms in both active and passive conditions. Gap evoked potentials in AN subjects appeared only with prolonged gap durations (10-50 ms). There was a close association between gap detection thresholds measured psychoacoustically and electrophysiologically in both normals and in AN subjects.Conclusions: Auditory cortical potentials can provide objective measures of auditory temporal processes.Significance: The combination of electrophysiological and psychoacoustic methods converged to provide useful objective measures for studying auditory cortical temporal processing in normals and hearing-impaired individuals. The procedure used may also provide objective measures of temporal processing for evaluating special populations such as children who may not be able to provide subjective responses. (c) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.