Highly enantioselective conjugate addition of dialkylzinc reagents to acyclic nitroalkenes:: A catalytic route to β2-amino acids, aldehydes, and alcohols
Highly enantioselective conjugate addition of dialkylzinc reagents to acyclic nitroalkenes:: A catalytic route to β2-amino acids, aldehydes, and alcohols
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DOI：
10.1021/ja029817d
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发表时间：
2003-04-02
影响因子：
15
通讯作者：
Feringa, BL
中科院分区：
文献类型：
--
作者：
Duursma, A;Minnaard, AJ;Feringa, BL
首次将手性亚磷酰胺配体（S，R，R）-L1用于无环硝基烯烃的共轭加成反应，获得了高达98%的对映选择性。使用具有不同二烷基锌试剂的无环底物提供了（官能化）β2-氨基醛、酸和醇的催化对映选择性路线。
Using chiral phosphoramidite ligand (S,R,R)-L1in the conjugate addition to acyclic nitroalkenes for the first time, we obtained enantioselectivities up to 98%. The use of acyclic substrates with different dialkylzinc reagents provides a catalytic enantioselective route to (functionalized) β2-amino aldehydes, acids, and alcohols.