Serum YKL-40 is increased in patients with hepatic fibrosis
Serum YKL-40 is increased in patients with hepatic fibrosis
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DOI：
10.1016/s0168-8278(00)80095-1
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发表时间：
2000-06-01
影响因子：
25.7
通讯作者：
Bendtsen, F
中科院分区：
文献类型：
--
作者：
Johansen, JS;Christoffersen, P;Bendtsen, F
背景/目的：YKL-40是几丁质酶家族的哺乳动物成员，是一种结合肝素和几丁质的凝集素，YKL-40的功能尚不清楚，但它可能在组织重塑中发挥作用。本研究的目的是评估各种类型和程度的慢性肝病患者的循环YKL-40水平及其与肝纤维化的可能关系。方法：采用放射免疫法测定129例疑似肝病患者的血清YKL-40水平，并与与血样同时进行的肝活检中YKL-40的组织学检查结果和免疫组化染色相关。结果：血清YKL-40中位数在慢性肝病患者中最高。酒精性肝硬化（532μg/I），特别是患有其他酒精性肝炎（740μg/I）的患者。酒精性肝硬化、肝炎后肝硬化(425μg/I)和非肝硬化纤维化(330μg/I)患者血清YKL-40显着高于正常人(102μg/I)、脂肪肝患者(195μg/I)或无纤维化病毒性肝炎患者(174μg/I)。血清 YKL-40 显着（p
Background/Aims: YKL-40, a mammalian member of the chitinase family, is a lectin that binds heparin and chitin, The function of YKL-40 is unknown, but it may function in tissue remodelling. The aims of this study were to assess the level of circulating YKL-40 in patients with various kinds and degree of chronic liver disease and its possible relation to liver fibrosis,Methods: Serum YKL-40 levels were determined by radioimmunoassay in 129 patients with suspected liver disease and related to histological findings and immunohistochemical staining of YKL-40 in a liver biopsy taken simultaneously with the blood sample.Results: The median serum YKL-40 was highest in patients with alcoholic cirrhosis (532 mu g/I), in particular in patients with additional alcoholic hepatitis (740 mu g/I). Patients with alcoholic cirrhosis, post-hepatitic cirrhosis (425 mu g/I) and non-cirrhotic fibrosis (330 mu g/I ) had significantly higher serum YKL-40 than normal subjects (102 mu g/I), patients with fatty liver (195 mu g/I) or patients with viral hepatitis without fibrosis (174 mu g/I). Serum YKL-40 was significantly (p