SPIN TRAPPING - KINETICS OF THE REACTION OF SUPEROXIDE AND HYDROXYL RADICALS WITH NITRONES
SPIN TRAPPING - KINETICS OF THE REACTION OF SUPEROXIDE AND HYDROXYL RADICALS WITH NITRONES
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DOI：
10.1021/ja00535a029
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发表时间：
1980-01-01
影响因子：
15
通讯作者：
RAUCKMAN, EJ
中科院分区：
文献类型：
--
作者：
FINKELSTEIN, E;ROSEN, GM;RAUCKMAN, EJ
研究了25℃下5，5-二甲基-1-吡咯啉‘-氧化物(DMPO)捕获超氧化物的速率常数与pH的关系。结果表明，02“·和H02·与DMPO的反应速率分别为10和6.6×101~(23)M~(-1)·S。用不同的方法测定了超氧化物捕获的速率常数，结果是一致的。根据动力学数据讨论了自旋捕获反应的机理。本文还报道了几种硝酮自旋陷阱捕获羟基自由基的动力学和这些加合物的稳定性。
The pH dependence of the rate constant for superoxide trapping by 5, 5-dimethyl-1-pyrroline’-oxide (DMPO) at 25 C is examined. The results indicate that either 02"· or H02· can react with DMPO, at rates of 10 and 6.6 X 101 23 M" 1 s'1, respectively. Rate constants for superoxide trapping are determined by different methods, and the results are consistent. Mechanistic aspects of the spin-trapping reaction are discussed in light of the kinetic data. The kinetics of hydroxyl radical trapping byseveral nitrone spin trapsand the stability of these adducts are also reported.