CROSSED CORTICOTHALAMIC AND THALAMOCORTICAL CONNECTIONS OF MACAQUE PREFRONTAL CORTEX
CROSSED CORTICOTHALAMIC AND THALAMOCORTICAL CONNECTIONS OF MACAQUE PREFRONTAL CORTEX
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DOI：
10.1002/cne.902570211
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发表时间：
1987-03-08
影响因子：
2.5
通讯作者：
GOLDMANRAKIC, PS
中科院分区：
文献类型：
--
作者：
PREUSS, TM;GOLDMANRAKIC, PS
我们进行了系统的比较同侧（非交叉）和对侧（交叉）的丘脑连接的前额叶皮质猕猴，使用皮质植入辣根过氧化物酶颗粒和四甲基联苯胺组织化学，以证明顺行和逆行丘脑标记。与普遍认为丘脑皮质投射是完全不交叉的相反，我们的研究结果表明，一个适度的交叉投射到前额皮质来自内侧丘脑，主要是前内侧和中线核。此外，虽然确认皮质丘脑的预测是双边的，我们发现，交叉的预测模式不同于非交叉的预测。投射到丘脑内侧核，特别是前内侧核，中线核，和大细胞的部分，mediodorsal核是双边的，对侧的投影几乎一样密集的同侧的投影。 向背内侧核和腹前核小细胞部的投射也是双侧的，但对侧投射远弱于同侧投射。前额叶投射到网状核、内侧枕、膝状体上核和界核似乎是完全同侧的。这些结果表明，前额叶皮层与丘脑近中区的核团有明显的双边和相互联系。由于间脑的这一区域在记忆功能的解剖学和行为学研究中有牵连，我们的研究结果表明，前额叶皮层，通过它与这一区域的连接，可能参与记忆系统的双边整合。
We have conducted a systematic comparison of the ipsilateral (uncrossed) and contralateral (crossed) thalamic connections of prefrontal cortex in macaque monkeys, using cortical implants of horseradish peroxidase pellets and tetramethyl benzidine histochemistry to demonstrate anterograde and retrograde thalamic labeling. Contrary to the prevailing belief that thalamocortical projections are entirely uncrossed, our findings indicate that a modest crossed projection to prefrontal cortex arises from the mesial thalamus, principally the anteromedial and midline nuclei. Also, while confirming that corticothalamic projections are bilateral, we found that the pattern of crossed projections differs from that of uncrossed projections. Projections to mesial thalamic nuclei, specifically to the anteromedial nucleus, the midline nuclei, and the magnocellular part of the mediodorsal nucleus are bilateral, the contralateral projection being nearly as dense as the ipsilateral projection. Projections to the parvicellular part of the mediodorsal and ventral anterior nuclei are also bilateral, but the contralateral projection is much weaker than the ipsilateral projection. Prefrontal projections to the reticular nucleus, medial pulvinar, suprageniculate nucleus, and limitans nucleus appear to be exclusively ipsilateral. These results indicate that prefrontal cortex has prominent bilateral and reciprocal connections with the nuclei of the mesial thalamic region. As this region of the diencephalon has been implicated by anatomical and behavioral studies in memory functions, our findings suggest that prefrontal cortex, through its connections with this region, may be involved in the bilateral integration of mnemonic systems.