Adiponectin and bone mass density: The InCHIANTI study.
Adiponectin and bone mass density: The InCHIANTI study.
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DOI：
10.1016/j.bone.2010.08.010
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发表时间：
2010-12
期刊：
影响因子：
4.1
通讯作者：
Incalzi RA
中科院分区：
文献类型：
--
作者：
Napoli N;Pedone C;Pozzilli P;Lauretani F;Ferrucci L;Incalzi RA
据报道，脂联素血清浓度与人体骨矿物质密度（BMD）呈负相关。然而，关于这个问题的数据由于研究样本量小和缺乏对身体成分的控制而存在偏差。我们使用了InCHIANTI研究第三次随访的数据，其中包括使用胫骨定量CT测量BMD和使用生物阻抗测量法测量身体成分。采用放射免疫法测定血清脂联素水平。我们排除了患有糖尿病、甲状腺功能亢进症、使用激素替代或皮质类固醇治疗的参与者。我们使用Pearson系数和线性回归模型评估脂联素与总骨密度、骨小梁骨密度和皮质骨密度的相关性，以估计脂联素与骨密度之间的相关性，控制潜在的混杂因素（年龄、体重指数、酒精摄入量、脂肪量、吸烟）。我们的样本由320名男性（平均年龄：67岁，SD：15.8，范围：29-97岁）和271名绝经后女性（平均年龄：76岁，SD：8.2，范围：42-97岁）组成。在男性中，血清脂联素与BMD无关。在女性中，校正潜在混杂因素后，脂联素与总BMD（β=-0.626，P<0.001）、骨小梁BMD（β=-0.696，P<0.001）和皮质BMD（β=-1.076，P= 0.001）相关。我们的研究结果表明，脂联素与女性骨量呈负相关。需要进一步的研究来证实这些发现的前瞻性，然后阐明解释机制。
Adiponectin serum concentration has been reported to be inversely correlated with bone mineral density (BMD) in humans. The data on this issue, however, are biased by small study sample size and lack of controlling for body composition. We used data from the third follow-up of the InCHIANTI study, which included measurements of BMD using quantitative CT of the tibia and of body composition using bioimpedenziometry. Serum adiponectin was measured using radioimmunoassay. We excluded participants with diabetes, hyperthyroidism, using hormone replacement or corticosteroid therapy. We evaluated the correlation of adiponectin with total, trabecular, and cortical BMD using Pearson’s coefficient, and linear regression models to estimate the association between adiponectin and BMD controlling for potential confounders (age, body mass index, alcohol intake, fat mass, smoking). Our sample was made up of 320 men (mean age: 67 years, SD: 15.8, range: 29–97 years) and 271 postmenopausal women (mean age: 76 years, SD: 8.2, range: 42–97 years). In men, serum adiponectin was not independently associated with BMD. In women, after correction for potential confounders, adiponectin was associated with total (β=−0.626, P<0.001), trabecular (β= −0.696, P<0.001), and cortical (β= −1.076, P= 0.001) BMD. Our results show that adiponectin is inversely associated with bone mass in women. Further studies are needed to confirm these findings prospectively and then to clarify the explanatory mechanisms.