Comparative Accuracy of 17 Point-of-Care Glucose Meters.
Comparative Accuracy of 17 Point-of-Care Glucose Meters.
复制标题
DOI：
10.1177/1932296816672237
复制
发表时间：
2017-05-01
影响因子：
5
通讯作者：
Russell, Steven J
中科院分区：
文献类型：
--
作者：
Ekhlaspour, Laya;Mondesir, Debbie;Russell, Steven J
背景：即时护理血糖仪（BG）的准确性对于血糖异常的检测、胰岛素剂量的计算和连续血糖监测仪的校准非常重要。本研究的目的是在一项具有挑战性的实验室研究中，使用具有广泛参考BG和血红蛋白值的样品，比较市售血糖仪的准确性。方法：来自医院STAT实验室的新鲜、丢弃的血液样本要么未经修饰使用，加入葡萄糖溶液，要么在37°C下孵育，产生347个样本，其参考BG水平从20到440 mg/dl，血红蛋白值从9到16 g/dl均匀分布。我们使用17种不同的市售血糖仪和参考方法（YSI 2300）同时测量每个样品的BG。我们确定了每个血糖仪的平均绝对相对差（MARD），根据参考BG和血红蛋白水平进行总体和分层。结果：不同仪表的准确度较广，mard范围为5.6% ~ 20.8%。在低血糖范围内，准确性较低，但在贫血血红蛋白水平的样本中，准确性并不总是较低。结论：市售血糖仪的准确度差异很大。尽管本研究中的样品混合比在大多数使用条件下收集的样品更具挑战性，但一些仪表在这些挑战中表现得很稳健，并且在这种设置中表现出很高的准确性。这些数据对具有挑战性的样品的相对准确性和稳健性可能有助于告知葡萄糖计的选择。
BACKGROUND: The accuracy of point-of-care blood glucose (BG) meters is important for the detection of dysglycemia, calculation of insulin doses, and the calibration of continuous glucose monitors. The objective of this study was to compare the accuracy of commercially available glucose meters in a challenging laboratory study using samples with a wide range of reference BG and hemoglobin values.METHODS: Fresh, discarded blood samples from a hospital STAT laboratory were either used without modification, spiked with a glucose solution, or incubated at 37°C to produce 347 samples with an even distribution across reference BG levels from 20 to 440 mg/dl and hemoglobin values from 9 to 16 g/dl. We measured the BG of each sample with 17 different commercially available glucose meters and the reference method (YSI 2300) at the same time. We determined the mean absolute relative difference (MARD) for each glucose meter, overall and stratified by reference BG and by hemoglobin level.RESULTS: The accuracy of different meters widely, exhibiting a range of MARDs from 5.6% to 20.8%. Accuracy was lower in the hypoglycemic range, but was not consistently lower in samples with anemic blood hemoglobin levels.CONCLUSIONS: The accuracy of commercially available glucose meters varies widely. Although the sample mix in this study was much more challenging than those that would be collected under most use conditions, some meters were robust to these challenges and exhibited high accuracy in this setting. These data on relative accuracy and robustness to challenging samples may be useful in informing the choice of a glucose meter.