Epidemiology and outcome of multiple-species candidemia at a tertiary care center between 2004 and 2007
Epidemiology and outcome of multiple-species candidemia at a tertiary care center between 2004 and 2007
复制标题
DOI：
10.1016/j.diagmicrobio.2009.03.010
复制
发表时间：
2009-07-01
影响因子：
2.9
通讯作者：
Neofytos, Dionissios
中科院分区：
文献类型：
--
作者：
Nace, Heather L.;Horn, David;Neofytos, Dionissios
多菌种念珠菌血症(MSC)在念珠菌血症病例中的发生率在2.8%至8.0%之间。我们试图在三级护理中心研究MSC的流行病学和预后。对2004-2007年间发生的MSC病例进行了回顾性分析。MSC定义为~gt；=2个不同的念珠菌。在同一血液培养瓶内或相隔72小时内同时生长。收集了有关人口统计学、合并症、抗真菌药物使用和存活率的信息。对40例MSC患者的81株念珠菌进行了鉴定。非白色念珠菌。(在81株分离株中，54株，66.7%)被发现的频率较高。最常见的组合是白色念珠菌/光滑念珠菌(15/40例，37.5%)，白色念珠菌/近缘念珠菌(8，20.0%)，光滑念珠菌/克鲁斯假丝酵母菌(5，12.5%)。总的4周和12周粗死亡率，不包括失去随访的患者，分别为41.9%和66.7%。在这一同期的MSC患者样本中，最常见的是白色念珠菌/光滑念珠菌的组合，死亡率很高。(C)2009 Elsevier Inc.保留所有权利。
The incidence of multiple-species candidemia (MSC) among cases of candidemia ranges between 2.8% and 8.0%. We sought to study the epidemiology and outcome of MSC at a tertiary care center. A retrospective analysis of MSC episodes occurring between 2004 and 2007 was performed. MSC was defined as >= 2 different Candida spp. growing concomitantly within the same blood culture bottle or within 72 h of each other. Information on demographics, comorbidities, antifungal use, and survival was collected. Forty MSC patients with 81 Candida isolates were identified. Non-albicans Candida spp. (54 of 81 isolates, 66.7%) were more frequently identified. The most common combinations observed were Candida albicans/Candida glabrata (15 of 40 patients, 37.5%), C. albicans/Candida parapsilosis (8, 20.0%), and C. glabrata/Candida krusei (5, 12.5%). The overall crude 4- and 12- week mortality, excluding patients lost to follow-up, was 41.9% and 66.7%, respectively. In this contemporary sampling of patients with MSC, the combination of C. albicans/C. glabrata was most frequently observed and mortality was high. (C) 2009 Elsevier Inc. All rights reserved.