A DELIVERY-INDEPENDENT BLOOD-FLOW EFFECT ON SKELETAL-MUSCLE FATIGUE
A DELIVERY-INDEPENDENT BLOOD-FLOW EFFECT ON SKELETAL-MUSCLE FATIGUE
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DOI：
10.1152/jappl.1986.61.3.1084
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发表时间：
1986-09-01
影响因子：
3.3
通讯作者：
BARCLAY, JK
中科院分区：
文献类型：
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作者：
BARCLAY, JK
对过度灌注通过增加O2和底物向肌肉的递送来降低肌肉疲劳的假设进行了测试。犬腓肠肌-跖肌原位制备物在自由流动控制期间以5 Hz刺激4 min，在泵灌注实验期间刺激20 min。通过降低呼吸100%O2（高O2/低流量）的动物的血流量[实验与对照比（E/C）= 0.97 + 0.02]或增加呼吸14%O2（低O2/高流量）的动物的血流量（E/C = 1.01 + 0.01），匹配这两个时期的O2输送。通过将血流量维持在稳态水平（恒定流量）（E/C = 0.98 + 0.10）或通过用右旋糖酐增加动物的流量以进行6%的血容量交换（稀释/高流量）（E/C = 1.02 + 0.02），在两个收缩期中匹配从血细胞比容估计到近似底物递送的血浆流量。初始拉伸的E/C为1.00 ± 0.02。在20分钟内，低O2/高流量下的展开张力下降15.0 ± 1.1%，稀/高流量下的展开张力下降16.0 ± 1.8%。在高O2/低流量和恒定流量下，张力分别降低28.0 ± 3.0和27.8 ± 1.5%。因此，高灌注减少疲劳的机制，独立于增加O2和底物输送。
The hypothesis that hyperperfusion decreases muscle fatigue by increasing O2 and substrate delivery to the muscle was tested. Canine gastrocnemius-plantaris in situ preparations were stimulated at 5 Hz for 4 min during a free-flow control period and for 20 min during a pump-perfused experimental period. O2 delivery during these two periods was matched either by decreasing blood flow in animals breathing 100% O2 (high O2/low flow) [experimental-to-control ratio (E/C) = 0.97 + 0.02] or by increasing the blood flow in animals breathing 14% O2 (low O2/high flow) (E/C = 1.01 + 0.01). Plasma flow estimated from hematocrit to approximate substrate delivery was matched in the two contraction periods either by maintaining blood flow at the steady-state level (contant flow) (E/C = 0.98 + 0.10) or by increasing flow in animals with a dextran for 6% of blood volume exchange (dilute/high flow) (E/C = 1.02 + 0.02). E/C for initial developed tension was 1.00 + 0.02. Over 20 min, developed tension decreased 15.0 + 1.1% with low O2/high flow and 16.0 + 1.8% with dilute/high flow. Tension decreased by 28.0 + 3.0 and 27.8 + 1.5% with high O2/low flow and constant flow, respectively. Thus hyperperfusion decreased fatigue by a mechanism independent of increased O2 and substrate delivery.