Metabolic Abnormalities in Pain-Processing Regions of Patients with Fibromyalgia: A 3T MR Spectroscopy Study
Metabolic Abnormalities in Pain-Processing Regions of Patients with Fibromyalgia: A 3T MR Spectroscopy Study
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DOI：
10.3174/ajnr.a2550
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发表时间：
2011-10-01
影响因子：
3.5
通讯作者：
Leonardi, M.
中科院分区：
文献类型：
--
作者：
Feraco, P.;Bacci, A.;Leonardi, M.
背景和目的：越来越多的证据表明大脑参与了FM。本质子磁共振波谱研究的目的是检验在处理疼痛的某些脑区存在代谢改变的假设材料和方法：12例FM患者，（30-54岁;平均年龄，43.2岁），和12 HC，年龄和性别匹配，进行了一次会议的单体素MRS进行3 T MR成像扫描仪。用PRESS获取MRS谱用于定位。使用LC模型评价每个光谱的原始数据。采用T检验评价各组间脑代谢产物的差异。结果：患者双侧VLPFC内Glx/Cr、Glu/Cr比值均显著高于HC（P <0.01）;丘脑代谢产物组间无显著差异。左侧丘脑Glu/Cr与疼痛VAS评分呈正相关（r = 0.730，P = .007）以及右侧VLPFC的mlns/Cr与疼痛VAS之间的差异（r = 0.607，P = .037）和FIQ结论：VLPFC中Glu/Cr水平升高强化了以下观点，即参与疼痛处理的不同脑区的复杂神经生理失衡是FM的基础。这些数据可能有助于诊断和开发更有效的药物治疗。
BACKGROUND AND PURPOSE: A growing body of evidence suggests the involvement of the brain in FM. The purpose of this proton MRS study was to test the hypothesis that there are metabolic alterations in some brain regions processing pain (VLPFC and thalamus) in patients with FM compared with HC.MATERIALS AND METHODS: Twelve patients with FM (30-54 years of age; mean age, 43.2 years), and 12 HC, matched for age and sex, underwent 1 session of single-voxel MRS performed on a 3T MR imaging scanner. MRS spectra were acquired with a PRESS for localization. The raw data from each spectrum was evaluated with an LCModel. T tests were used to evaluate differences of brain metabolites between groups. The Pearson correlation tested the relationship of metabolite ratios and clinical symptoms.RESULTS: Glx/Cr and Glu/Cr ratios within the VLPFC of both sides were significantly higher in patients than in HC (P < .01). No significant differences of metabolites between groups were found in the thalami. Positive correlations were found between Glu/Cr in the left thalamus and the VAS for pain (r = 0.730, P = .007) and between mlns/Cr in the right VLPFC and the VAS for pain (r = 0.607, P = .037) and the FIQ (r = 0.719, P = .008).CONCLUSIONS: The presence of elevated Glu/Cr levels in VLPFC strengthens the opinion that a complex neurophysiologic imbalance of different brain areas involved in pain processing underlies FM. These data may be useful in the diagnosis and development of more effective pharmacologic treatments.