Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
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DOI：
10.1086/428777
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发表时间：
2005-05-01
影响因子：
6.4
通讯作者：
Wong, JK
中科院分区：
文献类型：
--
作者：
Strain, MC;Little, SJ;Wong, JK
通过高活性抗逆转录病毒治疗（HAART）实现病毒学抑制的患者保留了人类免疫缺陷病毒1型（HIV-1）的长期细胞储存库；这种滞留是持续控制感染的障碍。为了评估在原发性HIV-1感染期间开始治疗对该细胞群的影响，我们分析了27名在之前或之前开始治疗的患者中HIV-1 DNA的衰变动力学和与体外活化细胞相关的传染性
Patients in whom virologic suppression is achieved with highly active antiretroviral therapy (HAART) retain long-lived cellular reservoirs of human immunodeficiency virus type 1 (HIV-1); this retention is an obstacle to sustained control of infection. To assess the impact that initiating treatment during primary HIV-1 infection has on this cell population, we analyzed the decay kinetics of HIV-1 DNA and of infectivity associated with cells activated ex vivo in 27 patients who initiated therapy before or