A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster
A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster
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DOI：
10.1038/sj.embor.embor897
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发表时间：
2003-08-01
期刊：
影响因子：
7.7
通讯作者：
Palmer, RH
中科院分区：
文献类型：
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作者：
Lorén, CE;Englund, C;Palmer, RH
黑腹果蝇基因间变性淋巴瘤激酶（Alk）与哺乳动物Alk同源，其编码受体酪氨酸激酶（RTK）的Alk/Ltk家族的成员。在人类中，t（2; 5）易位，其涉及ALK基因座，产生ALK的活性形式，其是非霍奇金淋巴瘤中的病原体。然而，Alk RTK的生理功能尚不清楚。在本文中，我们描述了果蝇Alk基因的功能丧失突变体，导致肠道发育完全失败。我们认为，在早期胚胎发育过程中，果蝇ALK的主要功能是内脏中胚层发育。
The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, which encodes a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans, the t(2; 5) translocation, which involves the ALK locus, produces an active form of ALK, which is the causative agent in non-Hodgkin's lymphoma. The physiological function of the Alk RTK, however, is unknown. In this paper, we describe loss-of-function mutants in the Drosophila Alk gene that cause a complete failure of the development of the gut. We propose that the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development.