Toward an understanding of the interaction between filarial parasites and host antigen-presenting cells.
Toward an understanding of the interaction between filarial parasites and host antigen-presenting cells.
复制标题
了解丝虫寄生虫和宿主抗原呈递细胞之间的相互作用。
DOI：
10.1111/j.0105-2896.2004.00196.x
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发表时间：
2004
影响因子：
8.7
通讯作者：
Nutman,ThomasB
中科院分区：
文献类型：
--
作者：
Semnani,RoshanakTolouei;Nutman,ThomasB
从免疫学的角度来看，淋巴丝虫感染是最复杂的寄生虫感染之一。不仅有不同的临床表现反映了不同的免疫反应，而且寄生虫的多个阶段，每个阶段都具有不同的解剖向性，给本已复杂的过程增添了复杂性。此外，这些寄生虫具有精细调整的免疫逃避策略，能够逃避先天免疫系统。由于寄生虫的不同阶段与不同类型的抗原呈递细胞相互作用，而这些细胞反过来可能在形成随后的适应性免疫反应中发挥重要作用，本综述的重点是深入了解丝虫寄生虫和抗原呈递细胞之间的相互作用，着眼于了解它们如何影响寄生虫抗原驱动的 T 细胞反应。
Lymphatic filarial infection, from an immunologic point of view, is one of the most complex parasite infections. Not only are there different clinical manifestations that reflect differing immune responses, but the parasite's multiple stages, each with distinct anatomic tropism, add a compartmental layer of complexity to an already complicated process. Moreover, these parasites have finely tuned immune evasion strategies that enable escape from the innate immune system. As different stages of the parasite interact with different types of antigen‐presenting cells that, in turn, may play a significant role in shaping the subsequent adaptive immune response, the focus of this review is to provide insight into the interaction between filarial parasites and antigen‐presenting cells with an eye toward understanding how they influence parasite antigen‐driven T‐cell responses.