The Discovery of Oxathiapiprolin: A New, Highly-Active Oomycete Fungicide with a Novel Site of Action
The Discovery of Oxathiapiprolin: A New, Highly-Active Oomycete Fungicide with a Novel Site of Action
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DOI：
10.1021/bk-2015-1204.ch011
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
R. J. Pasteris;Mary Ann Hanagan;J. Bisaha;B. L. Finkelstein;L. Hoffman;Vann Gregory;C. Shepherd;J. Andreassi;J. Sweigard;B. Klyashchitsky;Yewande T. Henry;R. A. Berger
中科院分区：
文献类型：
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作者：
R. J. Pasteris;Mary Ann Hanagan;J. Bisaha;B. L. Finkelstein;L. Hoffman;Vann Gregory;C. Shepherd;J. Andreassi;J. Sweigard;B. Klyashchitsky;Yewande T. Henry;R. A. Berger
Oxathiapiprolin是一类新的高活性卵菌杀菌剂胡椒酰噻唑异恶唑啉的第一个成员。它通过一种新的真菌靶点，一种氧甾醇结合蛋白起作用，对葡萄、土豆和蔬菜的关键疾病有良好的预防、治疗和残留功效。Oxathiapiprolin作为杜邦™Zorvec™疾病控制药物在全球范围内开发，预计将于2015年首次注册和销售。本文将对这类新化合物的发现、优化和功效进行综述。
Oxathiapiprolin is the first member of a new class of highly-active oomycete fungicides, the piperidinyl thiazole isoxazolines. It acts via a novel fungal target, an oxysterol binding protein, resulting in excellent preventative, curative and residual efficacy against key diseases of grapes, potatoes and vegetables. Oxathiapiprolin is being developed globally as DuPont™ Zorvec™ disease control with first registration and sales anticipated in 2015. The discovery, optimization and efficacy of this new chemical class will be reviewed.