Case only design to measure gene-gene interaction
Case only design to measure gene-gene interaction
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DOI：
10.1097/00001648-199903000-00014
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发表时间：
1999-03-01
期刊：
影响因子：
5.4
通讯作者：
Flanders, WD
中科院分区：
文献类型：
--
作者：
Yang, QH;Khoury, MJ;Flanders, WD
在暴露与基因型无关的假设下，单病例设计是筛选基因-环境交互作用的有效方法。在本文中，我们表明，只有情况下的设计也是一个有效的和有效的方法来衡量基因-基因的相互作用的假设下，基因的频率是独立的人口。正如仅病例设计需要比病例对照设计更少的病例来测量基因环境相互作用一样，它也需要更少的病例来测量基因-基因相互作用。
The case-only design is an efficient and valid approach to screening for gene-environment interaction under the assumption of the independence between exposure and genotype in the population. In this paper, we show that the case-only design is also a valid and efficient approach to measuring gene-gene interaction under the assumption that the frequencies of genes are independent in the population. Just as the case only design requires fewer cases than the case-control design to measure gene environment interaction, it also requires fewer cases to measure gene-gene interactions.