Genetic insights into the mechanisms of Fgf signaling.
Genetic insights into the mechanisms of Fgf signaling.
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DOI：
10.1101/gad.277137.115
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发表时间：
2016-04-01
影响因子：
10.5
通讯作者：
Soriano P
中科院分区：
文献类型：
--
作者：
Brewer JR;Mazot P;Soriano P
成纤维细胞生长因子 (Fgf) 配体和受体酪氨酸激酶家族是整个胚胎和出生后发育所必需的，并且还调节成人的多种稳态功能。在这里，布鲁尔等人。通过关注能够进行体内分析的遗传策略来回顾 Fgf 信号传导机制。成纤维细胞生长因子 (Fgf) 配体和受体酪氨酸激酶家族是整个胚胎和出生后发育所必需的，并且还调节成人的多种稳态功能。异常的 Fgf 信号传导会导致许多先天性疾病，并且是多种癌症的基础。因此，了解控制 Fgf 信号传导的机制对于了解 Fgf 生物学和疾病的许多方面非常重要。在这里，我们通过重点关注能够进行体内分析的遗传策略来回顾 Fgf 信号传导机制。这些研究支持 Erk1/2 作为 Fgf 信号传导在许多生物过程中的介导者的重要作用，但也为体内传递 Fgf 信号传导的其他信号通路提供了强有力的证据。
The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required throughout embryonic and postnatal development and also regulates multiple homeostatic functions in the adult. Here, Brewer et al. review the mechanisms of Fgf signaling by focusing on genetic strategies that enable in vivo analysis. The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required throughout embryonic and postnatal development and also regulates multiple homeostatic functions in the adult. Aberrant Fgf signaling causes many congenital disorders and underlies multiple forms of cancer. Understanding the mechanisms that govern Fgf signaling is therefore important to appreciate many aspects of Fgf biology and disease. Here we review the mechanisms of Fgf signaling by focusing on genetic strategies that enable in vivo analysis. These studies support an important role for Erk1/2 as a mediator of Fgf signaling in many biological processes but have also provided strong evidence for additional signaling pathways in transmitting Fgf signaling in vivo.