The roles of cohesins in mitosis, meiosis, and human health and disease.
The roles of cohesins in mitosis, meiosis, and human health and disease.
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DOI：
10.1007/978-1-4939-0888-2_11
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Berkowitz, Karen M
中科院分区：
文献类型：
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作者：
Brooker, Amanda S;Berkowitz, Karen M
有丝分裂和减数分裂是发育过程中必不可少的过程。在这些过程中，需要凝聚力来保持姐妹染色单体在一起，直到它们在后期分离。内聚是由称为内聚蛋白的多蛋白质亚基复合物产生的。虽然亚基在有丝分裂和减数分裂中略有不同，但典型的粘着蛋白复合物由四个非常不同的亚基组成。粘着蛋白复合物对于DNA修复、基因表达、发育和基因组完整性也很重要。在这里，我们提供了一个概述的作用cohesins在这些不同的事件，以及它们在人类健康和疾病，包括cohesinopathies的作用。虽然这些蛋白质的确切作用和机制仍在阐明，这篇评论将作为目前的知识cohesins的指导。
Mitosis and meiosis are essential processes that occur during development. Throughout these processes, cohesion is required to keep the sister chromatids together until their separation at anaphase. Cohesion is created by multi-protein subunit complexes called cohesins. Although the subunits differ slightly in mitosis and meiosis, the canonical cohesin complex is composed of four subunits that are quite diverse. The cohesin complexes are also important for DNA repair, gene expression, development, and genome integrity. Here we provide an overview of the roles of cohesins during these different events, as well as their roles in human health and disease, including the cohesinopathies. Although the exact roles and mechanisms of these proteins are still being elucidated, this review will serve as a guide for the current knowledge of cohesins.