Signaling in Host-Associated Microbial Communities.
Signaling in Host-Associated Microbial Communities.
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DOI：
10.1016/j.cell.2016.02.037
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发表时间：
2016-03-10
期刊：
影响因子：
64.5
通讯作者：
Segre JA
中科院分区：
文献类型：
--
作者：
Fischbach MA;Segre JA
人类相关的微生物群基于物种间的相互作用形成并稳定群落。我们回顾了这些微生物-微生物和微生物-宿主相互作用是如何传播的，以塑造人类一生中的社区，包括健康和疾病时期。建模和解剖宿主相关社区中的信号传导对于了解它们的功能至关重要，并将为预防或纠正微生物群落功能障碍以促进健康和治疗疾病的疗法打开大门。
Human-associated microbiota form and stabilize communities based on interspecies interactions. We review how these microbe-microbe and microbe-host interactions are communicated to shape communities over a human’s lifespan, including periods of health and disease. Modeling and dissecting signaling in host-associated communities is crucial to understand their function, and will open the door to therapies that prevent or correct microbial community dysfunction to promote health and treat disease.