Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study
Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study
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DOI：
10.1016/j.schres.2012.01.042
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发表时间：
2012-08-01
影响因子：
4.5
通讯作者：
Alexander, R.
中科院分区：
文献类型：
--
作者：
Murthy, N. V.;Mahncke, H.;Alexander, R.
最近的一项单中心研究（Fisher等人，2009.美国精神病学杂志166（7）805-11）表明，大脑健康计划（BFP）的重复训练提高了一系列神经心理任务的表现。如果重复这些数据表明一个重要的非药物方法，改善精神分裂症的认知障碍。我们的研究在一项开放标签、多中心、多国临床试验中评估了BFP培训的效果。55名稳定的成年精神分裂症患者定期服用抗精神病药物，在8-10周内完成了≥ 32次BFP训练。使用CogState（R）精神分裂症成套测验、UCSD基于表现的技能评估（UPSA-2）和认知评估访谈（CAI）来测量训练对认知表现和功能能力结果测量的影响。BFP训练对训练练习任务（听觉处理速度）显示出较大且显著的治疗效果，但该效果并未推广到独立CogState（R）评估的性能改善。对UPSA-2或CAI评分没有显着影响。我们的研究证明了在多地点研究中实施BFP培训的可行性。然而，尽管BFP训练对训练运动有很大的显著影响，但对认知能力或功能能力结果指标没有显示出显著的治疗效果。(C)2012爱思唯尔有限公司版权所有。
A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairment in schizophrenia. Our study evaluated the BFP training effects in an open-label, multi-site, multinational clinical trial. Fifty-five stable adult patients with schizophrenia on regular antipsychotic medication completed >= 32 BFP training sessions over 8-10 weeks. Training effects on cognitive performance and functional capacity outcome measures were measured using CogState (R) schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2) and Cognitive Assessment Interview (CAI). BFP training showed a large and significant treatment effect on a training exercise task (auditory processing speed), however this effect did not generalize to improved performance on independent CogState (R) assessment. There were no significant effects on UPSA-2 or CAI scores. Our study demonstrated the feasibility of implementing BFP training in a multi-site study. However, BFP training did not show significant treatment effects on cognitive performance or functional capacity outcome measures despite showing large and significant effects on a training exercise. (C) 2012 Elsevier B.V. All rights reserved.