Landanes and Sucrose Esters from Physalis sordida
Landanes and Sucrose Esters from Physalis sordida
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DOI：
10.1021/np100127k
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发表时间：
2010-07-01
影响因子：
5.1
通讯作者：
Maldonado, Emma
中科院分区：
文献类型：
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作者：
Perez-Castorena, Ana-L;Martinez, Mahinda;Maldonado, Emma
从酸浆地上部分分离得到8个新化合物，分别为labdanes 2-4，honmergostane 10和sucrose esters 12-15。新化合物的结构通过光谱学和化学转化进行了鉴定。10的结构通过其甲酯的X-射线晶体学分析证实。化合物1、2、4、5和12-15的抗炎活性使用TPA诱导的小鼠耳水肿试验来评价。化合物12（IC（50）0.26 μ mol/耳）和15（IC（50）0.24 μ mol/耳）显示与吲哚美辛（IC（50）0.24 μ mol/耳）相似的抗炎活性。
Eight new compounds, labdanes 2-4, honmergostane 10, and sucrose esters 12-15, were isolated from aerial parts of Physalis sordida together with several known compounds. Structures of the new compounds were elucidated using spectroscopic evidence and chemical transformations. The structure of 10 was confirmed by X-ray crystallographic analysis of its methyl ester. Anti-inflammatory activity of compounds 1, 2, 4, 5, and 12-15 was evaluated using the TPA-induced mouse ear edema test. Compounds 12 (IC(50) 0.26 mu mol/ear) and 15 (IC(50) 0.24 mu mol/ear) showed anti-inflammatory activity similar to that of indomethacin (IC(50) 0.24 mu mol/ear).