Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk
Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk
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DOI：
10.3945/ajcn.2008.26568
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发表时间：
2009-02-01
影响因子：
7.1
通讯作者：
White, Emily
中科院分区：
文献类型：
--
作者：
Maruti, Sonia S.;Ulrich, Cornelia M.;White, Emily
背景：很少有流行病学研究检查叶酸摄入量非常高以及参与一碳代谢的营养素的消耗是否与乳腺癌风险相关。目的：我们前瞻性地研究了自我报告的饮食摄入量（基线前一年）和补充剂（基线前平均超过 10 年）摄入的叶酸和一碳代谢营养素（蛋氨酸、核黄素和维生素 B-6 和 B-12）的摄入量是否与乳腺癌的发病率相关。设计：维生素与生活方式 (VITAL) 队列研究的参与者为 35,023 名 50-76 岁的绝经后女性；在基线（2000-2002）和 2006 年间，其中 743 名女性被诊断出乳腺癌。Cox 比例风险模型用于估计多变量调整后的相对风险 (RR) 和 95% CI。结果：每天摄入叶酸总量 >= 1272 膳食叶酸当量 (DFE)/天（10 年平均值）的女性与摄入叶酸的女性相比，患乳腺癌的风险降低了 22%
Background: Few epidemiologic studies have examined very high intakes of folate and whether consumption of nutrients involved in one-carbon metabolism is associated with breast cancer risk.Objective: We prospectively examined whether the consumption of folate and nutrients involved in one-carbon metabolism (methionine, riboflavin, and vitamins B-6 and B-12) from self-reported intakes of diet (in year before baseline) and supplements (averaged over 10 y before baseline) were associated with the incidence of breast cancer and breast cancer tumor characteristics.Design: Participants were 35,023 postmenopausal women aged 50-76 y in the VITamins And Lifestyle (VITAL) cohort study; breast cancer was diagnosed in 743 of these women between baseline (2000-2002) and 2006. Cox proportional hazards models were used to estimate multivariable-adjusted relative risks (RRs) and 95% CIs.Results: Women consuming >= 1272 dietary folate equivalents (DFE)/d of total folate (10-y average) had a 22% decrease in breast cancer risk compared with women consuming