Clinical Features of Carnitine Deficiency Secondary to Pivalate-Conjugated Antibiotic Therapy
Clinical Features of Carnitine Deficiency Secondary to Pivalate-Conjugated Antibiotic Therapy
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DOI：
10.1016/j.jpeds.2016.02.080
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发表时间：
2016-06-01
影响因子：
5.1
通讯作者：
Yamaguchi, Seiji
中科院分区：
文献类型：
--
作者：
Kobayashi, Hironori;Fukuda, Seiji;Yamaguchi, Seiji
目的探讨长期使用特戊酸结合抗生素（PCAs）引起的继发性肉毒碱缺乏症的临床特点和危险因素。研究设计我们回顾性调查了22例游离肉毒碱减少（C 0; = 14 d）的患者的年龄、临床表现、PCA给药时间和背景，其中6例患者在PCA给药后出现症状，其中6例患者在C 0; = 14 d后出现症状。
Objective To examine the clinical features and risk factors of secondary carnitine deficiency due to long-term use of pivalate-conjugated antibiotics (PCAs).Study design We retrospectively investigated the age, clinical manifestations, PCA administration period, and background of 22 patients who showed a decrease in free carnitine (C0; = 14 days, whereas 6 patients showed symptoms after PCA administration for