The ferric uptake regulator of Helicobacter pylori: a critical player in the battle for iron and colonization of the stomach.
The ferric uptake regulator of Helicobacter pylori: a critical player in the battle for iron and colonization of the stomach.
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DOI：
10.2217/fmb.13.43
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发表时间：
2013-06
影响因子：
3.1
通讯作者：
Merrell DS
中科院分区：
文献类型：
--
作者：
Pich OQ;Merrell DS
幽门螺杆菌可以说是最成功的病原体之一。它占据了超过一半人口的胃。在这样一个不适宜居住的生态位中的殖民和持续存在需要精致的适应机制的存在。对幽门螺杆菌的显着适应性有显着贡献的蛋白质之一是铁摄取调节因子 (Fur)，它充当基因表达的主调节因子。除了与铁稳态直接相关的基因外，毛皮还控制几种在新陈代谢和能量产生中发挥核心作用的酶的表达。 Fur 的缺乏会导致严重的幽门螺杆菌定植缺陷，因此，一些 Fur 调节基因已被证明对于定植至关重要。此外，毛皮调节基因编码的蛋白质对胃中的氧化还原稳态具有强烈影响，并且是炎症的主要决定因素。在这篇综述中，我们讨论了 Fur 在幽门螺杆菌生物学中的主要作用，并强调了这种调节蛋白在感染过程中的重要性。
Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarkable adaptability of H. pylori is the ferric uptake regulator (Fur), which functions as a master regulator of gene expression. In addition to genes directly related to iron homeostasis, Fur controls expression of several enzymes that play a central role in metabolism and energy production. The absence of Fur leads to severe H. pylori colonization defects and, accordingly, several Fur-regulated genes have been shown to be essential for colonization. Moreover, proteins encoded by Fur-regulated genes have a strong impact on redox homeostasis in the stomach and are major determinants of inflammation. In this review, we discuss the main roles of Fur in the biology of H. pylori and highlight the importance of this regulatory protein in the infectious process.