Comparative Physical Properties of Hyaluronic Acid Dermal Fillers
Comparative Physical Properties of Hyaluronic Acid Dermal Fillers
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DOI：
10.1111/j.1524-4725.2008.01046.x
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发表时间：
2009-02-01
影响因子：
2.4
通讯作者：
Gershkovich, Julia
中科院分区：
文献类型：
--
作者：
Kablik, Jeffrey;Monheit, Gary D.;Gershkovich, Julia
透明质酸（HA）填料正在成为用于化妆品软组织和皮肤矫正的首选材料。HA填料看起来是相似的，但它们的物理特性可能完全不同。这些差异有可能影响医生为患者提供自然和持久的结果的能力。本文的目的是讨论表征真皮填充物的关键物理性质和方法。然后用这些方法分析了几种常见的市售填料，得到了各种填料的性能数据。测量的物理性质是浓度，凝胶与流体的比例，HA凝胶浓度，HA改性程度，交联百分比，溶胀，模量，和particle.Results的结果表明，商业填料表现出各种各样的属性，结合影响填料性能的客观因素与临床经验，将为患者提供最佳的产品，以达到最佳的美容效果。对这些凝胶特性的仔细审查对于确定填充剂的选择、性能和患者的期望是必不可少的。Jeffrey Kablik、LiPing Yu、Grace Chang和Julia Gershkovich是Genzyme Corporation的员工。本研究中使用的材料由Genzyme提供。
Hyaluronic acid (HA) fillers are becoming the material of choice for use in cosmetic soft tissue and dermal correction. HA fillers appear to be similar, but their physical characteristics can be quite different. These differences have the potential to affect the ability of the physician to provide the patient with a natural and enduring result.The objective of this article is to discuss the key physical properties and methods used in characterizing dermal fillers. These methods were then used to analyze several well-known commercially available fillers.Analytical methods were employed to generate data on the properties of various fillers. The measured physical properties were concentration, gel-to-fluid ratio, HA gel concentration, degree of HA modification, percentage of cross-linking, swelling, modulus, and particle size.The results demonstrated that commercial fillers exhibit a wide variety of properties.Combining the objective factors that influence filler performance with clinical experience will provide the patient with the optimal product for achieving the best cosmetic result. A careful review of these gel characteristics is essential in determining filler selection, performance, and patient expectations.Jeffrey Kablik, LiPing Yu, Grace Chang, and Julia Gershkovich are employees of Genzyme Corporation. The materials used in this study were provided by Genzyme.