LIGHT-EVOKED CHANGES IN EXTRACELLULAR POTASSIUM CONCENTRATION IN MUDPUPPY RETINA
LIGHT-EVOKED CHANGES IN EXTRACELLULAR POTASSIUM CONCENTRATION IN MUDPUPPY RETINA
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DOI：
10.1016/0006-8993(78)90913-7
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发表时间：
1978-01-01
期刊：
影响因子：
2.9
通讯作者：
PROENZA, LM
中科院分区：
文献类型：
--
作者：
KARWOSKI, CJ;PROENZA, LM
光诱发的细胞外K+浓度（[K+]0）和场电位的变化，同时记录在响应各种各样的刺激，并在视网膜内的Necturus [maculosus]的不同深度。在光的起始和偏移，小直径的闪光刺激引起的[K+]0在近端视网膜的大幅增加。这种K+增加的深度分布与近端负反应（PNR）几乎相同，并且这两种反应对许多其他刺激参数表现出相似的行为。产生PNR的相同神经元可能是所观察到的K+通量的来源。大直径闪光刺激引起视网膜远端[K+] 0缓慢下降，近端略有增加。K+的增加发生在视网膜电图b波为正的深度处，也就是其电流源所在的位置。增加背景光强度降低远端视网膜中的[K+]0，并且通常增加近端的[K+]0。
Light-evoked changes in extracellular K+ concentration ([K+]0) and field potentials were recorded simultaneously in response to a wide variety of stimuli and at various depths within the retina of Necturus [maculosus]. At light onset and offset, small diameter flash stimuli elicited a large increase in [K+]0 in the proximal retina. The depth profile of this K+ increase was nearly identical to that of the proximal negative response (PNR), and both responses exhibited similar behavior to a number of other stimulus parameters. The same neurons which generate the PNR may be the source of the observed K+ flux. Large diameter flashed stimuli elicited a slow decrease in [K+)0 in the distal retina and a small increase proximally. The K+ increase occurred at a depth where the b-wave of the electroretinogram is positive going, and where its current source lies. Increasing background light intensity decreases [K+]0 in the distal retina, and generally increases [K+]0 proximally.