Trajectory encoding in the hippocampus and entorhinal cortex
Trajectory encoding in the hippocampus and entorhinal cortex
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DOI：
10.1016/s0896-6273(00)00018-0
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发表时间：
2000-07-01
期刊：
影响因子：
16.2
通讯作者：
Wilson, M
中科院分区：
文献类型：
--
作者：
Frank, LM;Brown, EN;Wilson, M
我们记录了大鼠海马和内嗅皮层（EC）的单个神经元，以研究这些结构在导航和记忆表征中的作用。我们的研究结果揭示了两个新现象：首先，当动物处于相同位置时，CA1和EC中的许多细胞以显著不同的速率发射，这取决于动物来自哪里或要去哪里。第二，EC深层的细胞，海马输出的目标，似乎代表了空间上不同的轨迹通过环境的位置之间的相似性。我们的研究结果表明，海马体代表了动物的位置，在通过空间的轨迹的背景下，EC代表跨不同的轨迹，可以允许概括的经验。
We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same position depending on where the animal had come from or where it was going. Second, cells in deep layers of the EC, the targets of hippocampal outputs, appeared to represent the similarities between locations on spatially distinct trajectories through the environment. Our findings suggest that the hippocampus represents the animal's position in the context of a trajectory through space and that the EC represents regularities across different trajectories that could allow for generalization across experiences.