Singlet oxygen generation photocatalyzed by TiO2 particles and its contribution to biomolecule damage
Singlet oxygen generation photocatalyzed by TiO2 particles and its contribution to biomolecule damage
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DOI：
10.1246/cl.2006.832
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发表时间：
2006-08-05
影响因子：
1.6
通讯作者：
Hirano, Toru
中科院分区：
文献类型：
--
作者：
Hirakawa, Kazutaka;Hirano, Toru
近红外发射的研究表明，通过分散在溶剂中的二氧化钛（TiO 2）的光催化反应，通过超氧化物生成单线态氧（O-1（2））。O-1（2）在TiO 2表面失活，不能氧化对TiO 2表面无亲和力的烟酰胺腺嘌呤二核苷酸。在磷脂膜中，光催化O-1（2）的产生被增强，并且水溶性蛋白质充当所产生的O-1（2）的有效清除剂。这些结果表明，由TiO 2产生的O-1（2）通过氧化膜蛋白参与光毒性效应。
The study of near-infrared emission has shown that singlet oxygen (O-1(2)) is generated via superoxide by the photocatalytic reaction of titanium dioxide (TiO2) dispersed in solvents. The O-1(2) was deactivated on the TiO2 surface and could not oxidize nicotinamide adenine dinucleotide, which has no affinity to the TiO2 surface. The generation of photocatalytic O-1(2) was enhanced in the phospholipid membrane, and a water soluble protein acted as an effective scavenger of the generated O-1(2). These findings suggest that O-1(2) generated by TiO2 contributes to the phototoxic effect through the oxidation of the membrane protein.