Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
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DOI：
10.1038/nm0496-405
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发表时间：
1996-04-01
期刊：
影响因子：
82.9
通讯作者：
Mann, DL
中科院分区：
文献类型：
--
作者：
Kaslow, RA;Carrington, M;Mann, DL
主要组织相容性复合体（MHC）基因（人类HLA）调节对外来抗原的免疫应答。分子和血清学技术被用来识别人类免疫缺陷病毒1型（HIV-1）的同性恋血清转换者中的HLA I类、II类和转运蛋白（TAP）基因（也是MHC的一部分）的产物。综合的统计分析产生了一个HLA图谱，可以预测从HIV-1感染到艾滋病发作的时间。在139名男性的队列中开发了该配置文件，并在第二个不相关的102名男性队列中进行了评估。在评估队列中，该配置文件区分艾滋病时间最短和最长的组之间的六倍差异（P = 0.001）。这些发现支持了目前关于HLA基因控制抗原加工的理论，并对HIV-1和其他感染的免疫发病机制有影响。
Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human immunodeficiency virus type 1 (HIV-1). Comprehensive statistical analysis produced an HLA profile that predicted time from HIV-1 infection to the onset of AIDS. The profile was developed in a cohort of 139 men and evaluated in a second unrelated cohort of 102 men. In the evaluation cohort, the profile discriminated a sixfold difference between groups with the shortest and longest times to AIDS (P = 0.001). These findings support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.