Effects of electrical stimulation of the central nucleus of the amygdala on the in vivo electrophysiological activity of rat nigral dopaminergic neurons.
Effects of electrical stimulation of the central nucleus of the amygdala on the in vivo electrophysiological activity of rat nigral dopaminergic neurons.
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电刺激杏仁核中央核对大鼠黑质多巴胺能神经元体内电生理活动的影响。
DOI：
10.1002/syn.890210410
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Freeman,AS
中科院分区：
文献类型：
--
作者：
Rouillard,C;Freeman,AS
杏仁中央核（CeA）接受来自中脑的多巴胺能（DA）神经支配。在其许多传出投射中，CeA支配黑质。探讨了CeA对黑质DA能神经元活动的影响。在麻醉大鼠上，观察了电刺激CeA对黑质DA能神经元放电频率和放电模式的影响。刺激后的时间直方图显示，黑质DA细胞被抑制（N = 15），兴奋（N = 13），或无反应（N = 17）CeA刺激（250刺激t 0.5 Hz）。抑制的平均（±SEM）潜伏期（24 ± 9 msec）显著短于兴奋的潜伏期（65 ± 10 msec）;抑制的持续时间（200 ± 29 msec）也显著大于兴奋的持续时间（86 ± 11 msec）（两者均P < 0.01）。兴奋的DA细胞基础放电频率显著低于抑制或无反应的DA细胞（P < 0.05）。初步数据表明，DA细胞爆发放电分别增加或减少，与刺激诱发的放电率增加或减少相关。刺激诱发反应的相对较长的潜伏期表明，CeA投射神经元通过多突触通路间接影响黑质DA神经元。这些结果表明，CeA有能力影响黑质DA神经元的活动，与CeA作为边缘系统和锥体外系之间的接口的假定作用一致。鉴于杏仁核在焦虑状态中的关键作用，这些发现表明DA细胞功能也可能在这些疾病中受到影响。© 1995 Wiley利斯公司
The central nucleus of the amygdala (CeA) receives a dopaminergic (DA) innervation from the midbrain. Among its many efferent projections, the CeA innervates the substantia nigra. The possibility that the CeA influences the activity of nigral DA neurons was evaluated. The effects of electrical stimulation of the CeA on the firing rate and pattern of nigral DA neurons were investigated in anesthetized rats. Poststimulus time histograms revealed that nigral DA cells were either inhibited (N = 15), excited (N = 13), or unresponsive (N = 17) to CeA stimulation (250 stimuli a t 0.5 Hz). The mean (±SEM) latency to inhibition (24 ± 9 msec) was significantly shorter than that for excitation (65 ± 10 msec); the duration of inhibition (200 ± 29 msec) was also significantly greater than the duration of excitation (86 ± 11 msec) (P < 0.01 for both). DA cells that were excited had basal firing rates significantly lower than those of the inhibited or unresponsive cells (P < 0.05). Preliminary data suggest that DA cell burst‐firing increases or decreases, respectively, in association with stimulation‐evoked increases or decreases in firing rate. The relatively long latencies for stimulation‐evoked responses suggest that CeA projection neurons indirectly affect nigral DA neurons via polysynaptic pathways. These results demonstrate that the CeA has the ability to influence the activity of nigral DA neurons, consistent with the putative role of the CeA as an interface between the limbic and extrapyramidal systems. Given the crucial role of the amygdala in anxiety states, these findings suggest that DA cell function may also be affected in such disorders. © 1995 Wiley‐Liss, Inc.