Shape-Switching Microrobots for Medical Applications: The Influence of Shape in Drug Delivery and Locomotion
Shape-Switching Microrobots for Medical Applications: The Influence of Shape in Drug Delivery and Locomotion
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DOI：
10.1021/acsami.5b00181
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发表时间：
2015-04-01
影响因子：
9.5
通讯作者：
Pane, Salvador
中科院分区：
文献类型：
--
作者：
Fusco, Stefano;Huang, Hen-Wei;Pane, Salvador
研究了水凝胶双层动态形状切换对自折叠微型机器人性能的影响，用于在身体孔口导航和按需释放药物。管状微型机器人是通过将温度响应性水凝胶纳米复合材料与聚（乙二醇）二丙烯酸酯（PEGDA）层耦合来制造的，以实现从平面矩形结构的自发和可逆折叠。将氧化石墨烯（GO）或二氧化硅涂覆的超顺磁性氧化铁纳米颗粒分散在温敏水凝胶基质中，以分别提供近红外（NIR）光敏性或磁致动。近红外光响应微结构被制造用于触发药物递送，而基于磁性纳米复合材料的微型机器人被用于分析形状在运动中的作用。管状结构的实验分析和计算机模拟表明，药物的释放和运动可以通过控制形状的变化进行优化。这些概念最后应用到螺旋微型机器人显示一种可能的方式来实现自主行为。
The effect of dynamic shape switching of hydrogel bilayers on the performance of self-folding microrobots is investigated for navigation in body orifices and drug release on demand. Tubular microrobots are fabricated by coupling a thermoresponsive hydrogel nanocomposite with a poly(ethylene glycol)diacrylate (PEGDA) layer, to achieve spontaneous and reversible folding from a planar rectangular structure. Graphene oxide (GO) or silica-coated superparamagnetic iron oxide nanoparticles are dispersed in the thermoresponsive hydrogel matrix to provide near-infrared (NIR) light sensitivity or magnetic actuation, respectively. The NIR light-responsive microstructures are fabricated for triggered drug delivery while magnetic nanocomposite-based microrobots are used to analyze the role of shape in locomotion. Experimental analysis and computational simulations of tubular structures show that drug release and motility can be optimized through controlled shape change. These concepts are finally applied to helical microrobots to show a possible way to achieve autonomous behavior.