Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls
Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls
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DOI：
10.1096/fj.02-0661fje
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发表时间：
2003-02-01
期刊：
影响因子：
4.8
通讯作者：
Weihe, P
中科院分区：
文献类型：
--
作者：
Grandjean, P;Budtz-Jorgensen, E;Weihe, P
母乳喂养与产后发育迟缓有关。虽然这种“断奶困境”的基础尚不清楚，但母乳中的环境污染物可能与此有关。我们研究了法罗群岛出生队列的182名单胎儿童，在1994-95年出生的术语。测量脐带血中汞的浓度和母乳中多氯联苯的浓度，并记录母乳喂养的持续时间。在18个月时，纯母乳喂养至少6个月的儿童体重比非母乳喂养的儿童轻0.59 kg [95%置信区间（CI）= 0.03，1.16 kg]，矮1.50 cm [95% CI = 0.52，2.47 cm]。然而，计算的污染物从人乳中转移完全解释了生长减弱。无论母乳喂养的持续时间如何，脐带血中汞浓度加倍与18个月时体重下降0.19 kg（95% CI = 0.03，0.35 kg）和身高下降0.26 cm（95% CI = 0.02，0.55 cm）相关。42月龄时的体重和身高表现出相同的趋势，但主要影响发生在18月龄之前。因此，在污染物暴露增加的社区中，在判断延长母乳喂养的益处时，必须考虑与哺乳期有毒物质转移到婴儿相关的风险。
Breast-feeding has been linked to slowed postnatal growth. Although the basis for this "weanling's dilemma" is unclear, environmental contaminants in human milk may be of relevance. We studied a Faroese birth cohort of 182 singleton children, born at term in 1994-95. Concentrations of mercury in cord blood and of polychlorinated biphenyls in maternal milk were measured, and duration of breast-feeding was recorded. At 18 months, children who had been exclusively breast-fed for at least 6 months weighed 0.59 kg less [95% confidence interval (CI) = 0.03, 1.16 kg] and were 1.50 cm [95% CI = 0.52, 2.47 cm] shorter than those not breast-fed. However, calculated transfer of contaminants from human milk fully explained the attenuated growth. Irrespective of duration of breast-feeding, a doubling of the mercury concentration in cord blood was associated with a decrease in weight at 18 months by 0.19 kg (95% CI = 0.03, 0.35 kg) and in height by 0.26 cm (95% CI = 0.02, 0.55 cm). Weight and height at 42 months showed the same tendencies, but the main effect occurred before 18 months of age. Thus, in communities with increased contaminant exposures, risks associated with lactational transfer of toxicants to the infant must be considered when judging the benefits of prolonged breast-feeding.