Neural correlates of perception of emotional facial expressions in out-patients with mild-to-moderate depression and anxiety. A multicenter fMRI study
Neural correlates of perception of emotional facial expressions in out-patients with mild-to-moderate depression and anxiety. A multicenter fMRI study
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DOI：
10.1017/s0033291711000596
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发表时间：
2011-11-01
影响因子：
6.9
通讯作者：
Aleman, A.
中科院分区：
文献类型：
--
作者：
Demenescu, L. R.;Renken, R.;Aleman, A.
背景抑郁症与对负面面部刺激的边缘系统过度激活和额叶低激活有关。焦虑症也与杏仁核和杏仁核等情绪结构的激活增加有关。本研究探讨了在多大程度上激活的大脑区域参与感知情绪的面孔是特定的抑郁症和焦虑症在一个大的社区为基础的样本的门诊病人。采用事件相关功能磁共振成像（fMRI）范式，包括愤怒，恐惧，悲伤，快乐和中性面部表情。182例门诊患者（59例抑郁症，57例焦虑症和66例抑郁焦虑共病）和56例健康对照组选自荷兰抑郁和焦虑研究（NESDA）被纳入本研究。进行全脑分析。杏仁核激活的时间分布也进行了研究。相对于杂乱的面孔，面部表情激活了伴有或不伴有焦虑的抑郁症患者和健康对照组的杏仁核和梭状回，但这在焦虑症患者中不太明显。杏仁核的反应形状在两组之间没有差异。与健康对照组相比，抑郁症患者在对快乐面孔的反应中表现出背外侧前额叶皮层（PFC）的过度激活。我们认为，更强的额叶激活，以快乐的面孔，抑郁症患者可能反映了增加的需求，努力的情绪调节过程中触发的情绪不一致的刺激。相对于健康对照组，对负面情绪面孔的神经激活缺乏强烈差异，这可能是该样本中轻度至中度疾病严重程度的特征，并可能表明一定的认知情绪处理储备。
Background. Depression has been associated with limbic hyperactivation and frontal hypoactivation in response to negative facial stimuli. Anxiety disorders have also been associated with increased activation of emotional structures such as the amygdala and insula. This study examined to what extent activation of brain regions involved in perception of emotional faces is specific to depression and anxiety disorders in a large community-based sample of out-patients.Method. An event-related functional magnetic resonance imaging (fMRI) paradigm was used including angry, fearful, sad, happy and neutral facial expressions. One hundred and eighty-two out-patients (59 depressed, 57 anxiety and 66 co-morbid depression-anxiety) and 56 healthy controls selected from the Netherlands Study of Depression and Anxiety (NESDA) were included in the present study. Whole-brain analyses were conducted. The temporal profile of amygdala activation was also investigated.Results. Facial expressions activated the amygdala and fusiform gyrus in depressed patients with or without anxiety and in healthy controls, relative to scrambled faces, but this was less evident in patients with anxiety disorders. The response shape of the amygdala did not differ between groups. Depressed patients showed dorsolateral prefrontal cortex (PFC) hyperactivation in response to happy faces compared to healthy controls.Conclusions. We suggest that stronger frontal activation to happy faces in depressed patients may reflect increased demands on effortful emotion regulation processes triggered by mood-incongruent stimuli. The lack of strong differences in neural activation to negative emotional faces, relative to healthy controls, may be characteristic of the mild-to-moderate severity of illness in this sample and may be indicative of a certain cognitive-emotional processing reserve.