The Rate of Antibody Formation in Monkeys Actively Immunized with Poliomyelitis Virus
The Rate of Antibody Formation in Monkeys Actively Immunized with Poliomyelitis Virus
复制标题
脊髓灰质炎病毒主动免疫猴的抗体形成率
作者：
M. Brodie
以前的报告（1）表明，通过皮肤接种病毒-血清混合物或亚感染剂量的含病毒组织可产生主动免疫，但后者产生的免疫力明显更强。因此，建议跟踪免疫的发生和随后的发展速率，如下：（a）单次亚感染剂量的含病毒组织，和（B）以不同的间隔接种两次。
虽然Römer和Joseph（2）声称只有在26天后才能在主动免疫中证明脊髓灰质炎抗体，但Leiner和Wiesner（3）在活动性疾病发展后7天，在一个病例中2天，Amoss（4）在3天半后发现了它们。同样，在这个实验室（5）中，在瘫痪高峰后的第二天，在猴子身上发现了抗体。在人类中，Netter和Levaditi（6）在疾病的第12天显示出抗病毒物质，Flexner和Amoss（7）在疾病的第6天显示出抗病毒物质。
In a previous report (1) it was shown that active immunity was produced by skin inoculation of virus-serum combinations, or sub-infective doses of virus-containing tissue, but that the latter gave decidedly more immunity. It is proposed, therefore, to trace the onset and subsequent rate of development of immunity following: (a) a single sub-infective dose of virus containing tissue, and (b) two inoculations, administered at different in-intervals.
Although Römer and Joseph (2) claimed that only after twenty-six days were antibodies for poliomyelitis demonstrable in active immunity, Leiner and Wiesner (3) found them after seven, and in one case, two days, and Amoss (4) three and one-half days after the development of the active disease. Likewise in this laboratory (5) antibody was found in monkeys on the second day after the height of paralysis. In human beings, Netter and Levaditi (6), showed antiviral substance on the twelfth day and Flexner and Amoss (7) on the sixth day of the disease.