PERSPECTIVES OF LONGITUDINAL GROWTH IN CYSTIC-FIBROSIS FROM BIRTH TO ADULT AGE
PERSPECTIVES OF LONGITUDINAL GROWTH IN CYSTIC-FIBROSIS FROM BIRTH TO ADULT AGE
复制标题
DOI：
10.1007/bf01958975
复制
发表时间：
1994-03-01
影响因子：
3.6
通讯作者：
GOTZ, M
中科院分区：
文献类型：
--
作者：
HAEUSLER, G;FRISCH, H;GOTZ, M
对139例囊性纤维化（CF）患者从出生到19岁的纵向生长进行了研究。出生时体重和身长已经降低（体重：女孩-0.83 +/- 0.13 SDS，男孩-0.44 +/- 0.13 SDS;身长：女孩-0.55 +/- 0.13 SDS，男孩-0.39 +/- 0.14 SDS;平均值+/- SEM）。两个变量均显示进一步下降，直至确诊（体重：女孩为-1.57 +/- 0.21 SDS，男孩为-1.46 +/- 0.25 SDS;身长：女孩为-1.15 +/- 0.32 SDS，男孩为-1.03 +/- 0.52 SDS;平均值+/- SEM）。诊断后6至12个月，身长改善，洗澡性别达到第25百分位。身高和体重在整个童年时期都处于第25百分位。在此期间，生长速度相当正常。8岁以后，身高和体重的体重都有所下降，青春期生长突增延迟和减少。然而，在青少年时期再次达到第25百分位。19岁时，女孩的身高中位数为161.5厘米，男孩为173厘米，均为第25百分位数。使用敏感的统计方法分析生长数据，我们提出了CF特定生长曲线的身高，体重和生长速度。肺定植铜绿假单胞菌对生长速度无显著影响。
The longitudinal growth in 139 patients with cystic fibrosis (CF) was investigated from birth until the age of 19 years. Already at birth weight and length were reduced (weight: -0.83 +/- 0.13 SDS in girls, -O.44 +/- 0.13 SDS in boys; length: -0.55 +/- 0.13 SDS in girls, -0.39 +/- 0.14 SDS in boys; mean +/- SEM). Both variables showed a further decline until diagnosis was established (weight: -1.57 +/- 0.21 SDS in girls, -1.46 +/- 0.25 SDS in boys; length: -1.15 +/- 0.32 SDS in girls, -1.03 +/- 0.52 SDS in boys; mean +/- SEM). Six to 12 months after diagnosis length improved and reached the 25th percentile in bath sexes. Height and weight followed the 25th percentile throughout childhood. Growth velocity was fairly normal during this period. There was a loss in percentiles of both height and weight after the age of 8 years and the pubertal growth spurt was delayed and reduced. However, the 25th percentile was reached again in the adolescent period. At the age of 19 years median height was 161,5 cm in girls and 173 cm in boys, both representing the 25th percentile. Using a sensitive statistical method for analysis of growth data we present CF specific growth curves for height, weight and growth velocity. There was no significant effect of pulmonary colonization with Pseudomonas aeroginosa on growth velocity.