Risk of epilepsy in rheumatoid arthritis: a meta-analysis of population based studies and bioinformatics analysis
Risk of epilepsy in rheumatoid arthritis: a meta-analysis of population based studies and bioinformatics analysis
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类风湿性关节炎的癫痫风险：基于人群的研究和生物信息学分析的荟萃分析
DOI：
10.1177/2040622319899300
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发表时间：
2020-01
影响因子：
3.5
通讯作者：
Xu Zhenghao
中科院分区：
文献类型：
--
作者：
Zhao Huawei;Li Shan;Xie Meijuan;Chen Rongrong;Lu Haimei;Wen Chengping;Filiano Anthony J.;Xu Zhenghao
背景：越来越多的研究支持类风湿性关节炎（RA）和脑部疾病之间的关联。本研究旨在确定RA与癫痫之间的关系。方法：全面检索中英文数据库。所选研究的数据由两位作者独立提取和分析。还收集并分析了与癫痫和RA相关的基因。结果：我们纳入了6项全国性的基于人群的研究（共n = 7，094，113例）进行荟萃分析。RA患者[风险比（RR）= 1.601; 95%置信区间（CI）：1.089-2.354; p = 0.017; n = 3，803，535例]和母亲患有RA的儿童癫痫风险增加（RR = 1.475; 95% CI：1.333-1.633; p < 0.001，n = 3，290，578例）。亚组分析和Meta回归分析显示RA患者癫痫的RR与年龄呈负相关。此外，我们发现，433个基因的共表达网络从129例癫痫患者的大脑中富集在RA和相关的京都基因和基因组途径百科全书，而13个基因（主要涉及炎症细胞因子和趋化因子）被确定为潜在的关键基因桥接RA和癫痫。结论：我们的研究，利用荟萃分析和生物信息学数据，突出了癫痫和类风湿关节炎之间的密切联系。进一步的研究仍有必要扩大这些发现，特别是对于在胎儿和儿童时期暴露于RA的人群。
Background: An increasing number of studies support an association between rheumatoid arthritis (RA) and brain disorders. This study aims to determine the association between RA and epilepsy. Methods: A comprehensive search of databases in both English and Chinese was performed. Data from the selected studies were extracted and analyzed independently by two authors. Genes associated with epilepsy and RA were also collected and analyzed. Results: We included six nationwide population based studies (n = 7,094,113 cases in total) for the meta-analysis. The risk of epilepsy was increased in RA patients [risk ratio (RR) = 1.601; 95% confidence interval (CI): 1.089–2.354; p = 0.017; n = 3,803,535 cases] and children born to mothers with RA (RR = 1.475; 95% CI: 1.333–1.633; p < 0.001, n = 3,290,578 cases). Subgroup analysis and meta-regression showed the RR of epilepsy in RA was negatively correlated with age. Furthermore, we found that 433 identified genes in a coexpression network from the hippocampi of 129 epileptic patients were enriched in the RA and related Kyoto Encyclopedia of Genes and Genomes pathways, while 13 genes (mainly related to inflammatory cytokines and chemokines) were identified as potential key genes bridging the RA and epilepsy. Conclusions: Our study, utilizing meta-analysis and bioinformatical data, highlights a close association between epilepsy and RA. Further studies are still warranted to expand these findings, especially for a population that is exposed to RA during fetal and childhood periods.
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影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
5.1
作者：
Weyand CM;Yang Z;Goronzy JJ
通讯作者：
Goronzy JJ
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
1.6
作者：
Chang KH;Hsu YC;Chang MY;Lin CL;Wu TN;Hwang BF;Chen CY;Liu HC;Kao CH
通讯作者：
Kao CH
影响因子：
3.3
作者：
T. Nishioku;K. Furusho;A. Tomita;H. Ohishi;S. Dohgu;H. Shuto;A. Yamauchi;Y. Kataoka
通讯作者：
T. Nishioku;K. Furusho;A. Tomita;H. Ohishi;S. Dohgu;H. Shuto;A. Yamauchi;Y. Kataoka