Discovery of Swine as a Host for the Reston ebolavirus
Discovery of Swine as a Host for the Reston ebolavirus
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DOI：
10.1126/science.1172705
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发表时间：
2009-07-10
期刊：
影响因子：
56.9
通讯作者：
McIntosh, Michael T.
中科院分区：
文献类型：
--
作者：
Barrette, Roger W.;Metwally, Samia A.;McIntosh, Michael T.
自从发现马尔堡和埃博拉丝状病毒物种以来，人类和非人类灵长类动物中看似随机的、散发的致命疾病暴发推动了对宿主嗜性和潜在宿主的识别。菲律宾的家猪正在经历异常严重的猪生殖和呼吸系统疾病综合征暴发，现已发现它们携带雷斯顿埃博拉病毒（REBOV）。虽然REBOV是丝状病毒科唯一未与人类疾病相关的成员，但它在人类食物链中的出现令人担忧。研究发现，与1989年分离的原病毒相比，REBOV分离株之间的差异更大，这表明REBOV起源于多系，并且自首次在猴子中发现REBOV以来，甚至可能在此之前，REBOV就一直在传播。
Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.