Sleep disturbance, stroke, and heart disease events: evidence from the Caerphilly cohort
Sleep disturbance, stroke, and heart disease events: evidence from the Caerphilly cohort
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DOI：
10.1136/jech.2005.039057
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发表时间：
2006-01-01
影响因子：
6.3
通讯作者：
Gallacher, J
中科院分区：
文献类型：
--
作者：
Elwood, P;Hack, M;Gallacher, J
目的：检验睡眠障碍与老年男性缺血性中风和缺血性心脏病事件风险相关的假设。设计：一项队列研究。背景：卡菲利队列，英国南威尔士老年男性的代表性人群样本。参与者：1986 名 55 - 69 岁的男性在伴侣的帮助下完成了一份关于睡眠模式的调查问卷。该调查询问了睡眠障碍的症状：失眠、打鼾、腿不安、阻塞性睡眠呼吸暂停以及白天嗜睡。在接下来的 10 年里，107 名男性经历了缺血性中风，213 名男性经历了缺血性心脏病。主要结果：多达三分之一的男性报告至少一种暗示睡眠障碍的症状，三分之一的男性报告白天嗜睡。与没有报告此类症状的男性相比，有任何睡眠障碍的男性发生缺血性中风的调整后相对几率显着增加，其中与睡眠呼吸暂停的关联最强（相对几率1.97；1.26至3.09）。与白天嗜睡对于中风的关联并不显着。在有睡眠障碍症状的男性中，与缺血性心脏病事件的相关性均升高，但除了白天嗜睡外，没有任何显着性（相对几率：1.41；1.04 至 1.92）。与血压没有显着关系。 结论：睡眠经常受到干扰的男性，缺血性中风的风险增加，白天嗜睡与缺血性心脏病事件的显着增加相关。
Objective: To test the hypothesis that sleep disorders are relevant to the risk of ischaemic stroke and ischaemic heart disease events in older men.Design: A cohort study.Setting: The Caerphilly cohort, a representative population sample of older men in South Wales, UK.Participants: 1986 men aged 55 - 69 years completed a questionnaire on sleep patterns with help from their partners. This asked about symptoms of disturbed sleep: insomnia, snoring, restless legs, obstructive sleep apnoea, and about daytime sleepiness. During the following 10 years 107 men experienced an ischaemic stroke and 213 had an ischaemic heart disease event.Main results: Up to one third of the men reported at least one symptom suggestive of sleep disturbance, and one third reported daytime sleepiness. Compared with men who reported no such symptoms, the adjusted relative odds of an ischaemic stroke were significantly increased in men with any sleep disturbance, the strongest association being with sleep apnoea ( relative odds 1.97; 1.26 to 3.09). The association with daytime sleepiness was not significant for stroke. Relations with ischaemic heart disease events were all raised in men with symptoms of sleep disturbance, but none was significant, other than daytime sleepiness ( relative odds: 1.41; 1.04 to 1.92). There were no significant relations with blood pressure.Conclusion: The risk of an ischaemic stroke is increased in men whose sleep is frequently disturbed, and daytime sleepiness is associated with a significant increase in ischaemic heart disease events.