Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation
Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation
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DOI：
10.1016/s0012-1606(03)00210-0
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发表时间：
2003-08-01
影响因子：
2.7
通讯作者：
Soares, MJ
中科院分区：
文献类型：
--
作者：
Ain, R;Canham, LN;Soares, MJ
血绒膜胎座形成的特征是滋养层细胞侵入子宫壁。在这份报告中，我们研究了滋养层细胞在大鼠和小鼠的侵袭，侵袭性滋养层细胞的内分泌表型，滋养层细胞侵袭的调节方面。在大鼠中，滋养层细胞表现出广泛的间质和血管内浸润。滋养层细胞穿透蜕膜并进入子宫腺，在那里它们与脉管系统形成密切的联系。小鼠滋养层细胞的侵袭主要是间质性的，仅限于子宫系膜蜕膜。间质和血管内大鼠滋养层细胞合成一组独特的催乳素（PRL）样激素/细胞因子，PRL样蛋白-A（PLP-A），PLP-L和PLP-M。侵入的小鼠滋养层细胞也具有内分泌活性，包括PLP-M和PLP-N的表达。自然杀伤（NK）细胞和滋养层细胞在大鼠和小鼠子宫系膜内的运输是相互的。随着NK细胞从子宫系膜室消失，滋养层细胞亚群离开绒毛尿囊胎盘并进入蜕膜。此外，在NK细胞遗传缺陷的小鼠（Tgepsilon 26小鼠）中，间质滋养层细胞侵袭的开始加速，暗示NK细胞在滋养层细胞侵袭中可能的调节作用。此外，NK细胞产物干扰素-γ（IFN γ）抑制滋养层细胞生长，并且在具有IFN γ或IFN γ受体的遗传缺陷的小鼠中滋养层细胞侵袭加速。总之，滋养层细胞在大鼠和小鼠妊娠的最后一周侵入子宫壁，并具有独特的内分泌表型，子宫系膜隔室中存在的因子调节其侵入行为。(C)2003 Elsevier Science（美国）。All rights reserved.
Trophoblast cell invasion into the uterine wall is characteristic of hemochorial placentation. In this report, we examine trophoblast cell invasion in the rat and mouse, the endocrine phenotype of invasive trophoblast cells, and aspects of the regulation of trophoblast cell invasion. In the rat, trophoblast cells exhibit extensive interstitial and endovascular invasion. Trophoblast cells penetrate through the decidua and well into the metrial gland, where they form intimate associations with the vasculature. Trophoblast cell invasion in the mouse is primarily interstitial and is restricted to the mesometrial decidua. Both interstitial and endovascular rat trophoblast cells synthesize a unique set of prolactin (PRL)-like hormones/cytokines, PRL-like protein-A (PLP-A), PLP-L, and PLP-M. Invading mouse trophoblast cells also possess endocrine activities, including the expression of PLP-M and PLP-N. The trafficking of natural killer (NK) cells and trophoblast cells within the mesometrial uterus is reciprocal in both the rat and mouse. As NK cells disappear from the mesometrial compartment, a subpopulation of trophoblast cells exit the chorioallantoic placenta and enter the decidua. Furthermore, the onset of interstitial trophoblast cell invasion is accelerated in mice with a genetic deficiency of NK cells, Tgepsilon26 mice, implicating a possible regulatory role of NK cells in trophoblast cell invasion. Additionally, the NK cell product, interferon-gamma (IFNgamma), inhibits trophoblast cell outgrowth, and trophoblast cell invasion is accelerated in mice with a genetic deficiency in the IFNgamma or the IFNgamma receptor. In summary, trophoblast cells invade the uterine wall during the last week of gestation in the rat and mouse and possess a unique endocrine phenotype, and factors present in the uterine mesometrial compartment modulate their invasive behavior. (C) 2003 Elsevier Science (USA). All rights reserved.