HIGH-DENSITIES OF BENZODIAZEPINE RECEPTORS IN HUMAN CORTICAL AREAS
HIGH-DENSITIES OF BENZODIAZEPINE RECEPTORS IN HUMAN CORTICAL AREAS
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DOI：
10.1038/269702a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
SQUIRES, RF
中科院分区：
文献类型：
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作者：
BRAESTRUP, C;ALBRECHTSEN, R;SQUIRES, RF
目前已确定大鼠脑细胞膜中存在脑特异性苯二氮受体1 -4。各种苯二氮卓类药物对大鼠脑中苯二氮卓类受体位点的亲和力与几个种属中临床预测药理活性之间的高度显著相关性，强烈表明体外苯二氮卓类受体与体内苯二氮卓类药物的生理相关受体相关。我们在这里报告说，苯二氮卓类受体也存在于人脑中，大脑和小脑皮质区域含有最高密度的结合位点，并且人脑中的受体与大鼠大脑中的受体非常相似。
THE presence of brain-specific benzodiazepine receptors in membranes from rat brain is now established1–4. Highly significant correlations between the affinities of various benzodiazepines for the benzodiazepine receptor site in rat brain on the one hand and clinically predictive pharmacological activities in several species on the other, strongly suggest that the benzodiazepine receptorin vitrois related to a physiologically relevant receptor for benzodiazepinesin vivo. We report here that benzodiazepine receptors are also present in the human brain, that the cerebral and cerebellar cortical regions contain the highest densities of binding sites and that the receptors in human brain are very similar to those in rat brain.