Self‐regulating hyperthermia induced using thermosensitive ferromagnetic material with a low Curie temperature
Self‐regulating hyperthermia induced using thermosensitive ferromagnetic material with a low Curie temperature
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DOI：
10.1111/j.1349-7006.2008.00726.x
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发表时间：
2008-04
期刊：
影响因子：
5.7
通讯作者：
H. Saito;K. Mitobe;Aki Ito;Y. Sugawara;K. Maruyama;Y. Minamiya;S. Motoyama;N. Yoshimura;J. Ogawa
中科院分区：
文献类型：
--
作者：
H. Saito;K. Mitobe;Aki Ito;Y. Sugawara;K. Maruyama;Y. Minamiya;S. Motoyama;N. Yoshimura;J. Ogawa
热疗已被用于治疗多种恶性肿瘤多年。居里温度（Tc）是磁性材料失去其磁性的转变点，导致电流停止，从而产生热量。由于热敏材料的自我调节性质，Tc能够在整个肿瘤中自动控制温度。我们开发了一种磁诱导热疗方法，使用具有低Tc（43°C）的热敏铁磁颗粒（FMP），足以介导自动温度控制。将B16黑色素瘤细胞皮下注射到C57 BL/6小鼠的背部，之后使肿瘤生长至直径为5 mm。然后将FMPs注射到肿瘤中，并将小鼠分为三组：组I（无热疗，对照）;组II（一次热疗治疗）;和组III（每周两次热疗，持续4周）。当暴露于磁场时，FMP显示出产热急剧上升，在7分钟内达到组织中的Tc，之后组织温度稳定在大约Tc。在组I和组II中，所有小鼠在30-45天内死亡。然而，在第III组中，10只小鼠中有6只在开始治疗后120天仍存活。我们的研究结果表明，通过低Tc的FMPs介导的磁诱导自我调节热疗重复治疗是抑制黑色素瘤生长的有效方法。这种热疗系统的一个关键优点是它是微创的，只需要一次注射就可以进行自动温度控制的重复治疗。（Cancer Sci 2008; 99：805-809）
Hyperthermia has been used for many years to treat a variety of malignant tumors. The Curie temperature (Tc) is a transition point at which magnetic materials lose their magnetic properties, causing a cessation of current and thus heat production. The Tc enables automatic temperature control throughout a tumor as a result of the self‐regulating nature of the thermosensitive material. We have developed a method of magnetically‐induced hyperthermia using thermosensitive ferromagnetic particles (FMPs) with low Tc (43°C), enough to mediate automatic temperature control. B16 melanoma cells were subcutaneously injected into the backs of C57BL/6 mice, after which tumors were allowed to grow to 5 mm in diameter. FMPs were then injected into the tumors, and the mice were divided into three groups: group I (no hyperthermia, control); group II (one hyperthermia treatment); and group III (hyperthermia twice a week for 4 weeks). When exposed to a magnetic field, the FMPs showed a sharp rise in heat production, reaching the Tc in tissue within 7 min, after which the tissue temperature stabilized at approximately the Tc. In groups I and II, all mice died within 30–45 days. In group III, however, 6 of 10 mice remained alive 120 days after beginning treatment. Our findings suggest that repeated treatment with magnetically‐induced self‐regulating hyperthermia, mediated by FMPs with a low Tc, is an effective means of suppressing melanoma growth. A key advantage of this hyperthermia system is that it is minimally invasive, requiring only a single injection for repeated treatments with automatic temperature control. (Cancer Sci 2008; 99: 805–809)