A Versatile Synthesis of Various Substituted Taurines from Vicinal Amino Alcohols and Aziridines
A Versatile Synthesis of Various Substituted Taurines from Vicinal Amino Alcohols and Aziridines
复制标题
由邻氨基醇和氮丙啶多功能合成各种取代牛磺酸
DOI：
10.1002/ejoc.200900759
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发表时间：
2009-11-01
影响因子：
2.8
通讯作者：
Xu, Jiaxi
中科院分区：
文献类型：
--
作者：
Chen, Ning;Jia, Weiyi;Xu, Jiaxi
牛磺酸和结构上不同的取代牛磺酸已通过过氧甲酸氧化由邻位氨基醇或氮丙啶和二硫化碳产生的噻唑烷-2-酮中间体合成。讨论了反应的立体化学和机理。该方法是一种无盐和通用的路线，在纯化方面方便，并且可用于合成光学活性的取代牛磺酸。（© Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2009）
Taurine and structurally diverse substituted taurines have been synthesized by peroxyformic acid oxidation of the thiazolidine-2-thione intermediates generated from vicinal amino alcohols or aziridines and carbon disulfide. Thestereochemistry and mechanisms of the reactions are disscussed. The method is a salt-free and versatile route, convenient in terms of purification, and can be used to synthesize optically active substituted taurines. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)