Diabetes-related symptom distress in association with glucose metabolism and comorbidity: the Hoorn Study.
Diabetes-related symptom distress in association with glucose metabolism and comorbidity: the Hoorn Study.
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DOI：
10.2337/dc08-1074
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发表时间：
2008-12
期刊：
影响因子：
16.2
通讯作者：
Snoek FJ
中科院分区：
文献类型：
--
作者：
Adriaanse MC;Pouwer F;Dekker JM;Nijpels G;Stehouwer CD;Heine RJ;Snoek FJ
目的：本研究的目的是确定糖尿病相关症状窘迫、糖代谢状态和2型糖尿病合并症之间的关系。研究设计和方法：这是一个横断面样本，包括281例糖代谢正常（NGM）、181例糖代谢受损（IGM）和107例2型糖尿病患者。我们使用修订后的2型糖尿病症状检查表（DSC-R）来评估糖尿病相关症状窘迫。结果：糖尿病患者的总症状困扰评分（范围0-100）相对较低（平均±SD 8.4±9.4），但与IGM组（6.5±7.1）和NGM组（6.1±7.9）有显著差异（F = 3.1, 2 d.f, P = 0.046）。缺血性心脏病在三个亚量表上与DSC-R评分升高相关，而抑郁症在所有DSC-R域均表现出较高的症状窘迫水平。结论：糖代谢恶化与糖尿病相关症状窘迫增加有关。这种关系因缺血性心脏病，尤其是抑郁症而减弱。
OBJECTIVE—The purpose of this study was to determine the associations between diabetes-related symptom distress, glucose metabolism status, and comorbidities of type 2 diabetes. RESEARCH DESIGN AND METHODS—This was a cross-sectional sample of 281 individuals with normal glucose metabolism (NGM), 181 individuals with impaired glucose metabolism (IGM), and 107 subjects with type 2 diabetes. We used the revised type 2 Diabetes Symptom Checklist (DSC-R) to assess diabetes-related symptom distress. RESULTS—The total symptom distress score (range 0–100) was relatively low for diabetic subjects (mean ± SD 8.4 ± 9.4), although it was significantly different from that for subjects with IGM (6.5 ± 7.1) and NGM (6.1 ± 7.9) (F = 3.1, 2 d.f., P = 0.046). Ischemic heart disease was associated with elevated DSC-R scores on three subscales, whereas depression showed higher symptom distress levels across all DSC-R domains. CONCLUSIONS—Worsening glucose metabolism is associated with increasing diabetes-related symptom distress. This relationship is attenuated by ischemic heart disease and particularly by depression.
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影响因子：
120.7
作者：
Golden, Sherita Hill;Lazo, Mariana;Lyketsos, Constantine
通讯作者：
Lyketsos, Constantine
影响因子：
1.2
作者：
RADLOFF L S
通讯作者：
RADLOFF L S
影响因子：
120.7
作者：
Testa, MA;Simonson, DC
通讯作者：
Simonson, DC
影响因子：
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作者：
Jager, A;Kostense, PJ;Stehouwer, CDA
通讯作者：
Stehouwer, CDA
影响因子：
7
作者：
Ciechanowski, PS;Katon, WJ;Hirsch, IB
通讯作者：
Hirsch, IB