Topology of three-way junctions in folded RNAs
Topology of three-way junctions in folded RNAs
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DOI：
10.1261/rna.2208106
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发表时间：
2006-01-01
期刊：
影响因子：
4.5
通讯作者：
Westhof, E
中科院分区：
文献类型：
--
作者：
Lescoute, A;Westhof, E
对折叠rna的x射线结构中包含的三向结进行了编译和分析。根据连接三个沃森-克里克螺旋的片段的相对长度，两个螺旋近似同轴堆叠的三通结可以分为三个主要家族。每个家族都具有拓扑特征，并且在非沃森中具有一定的守恒性。-在连接段内以及在段和螺旋之间的接触类型中点击配对。最多的家族表现为两个螺旋之间的三级相互作用，以及连接段和第三螺旋之间广泛的浅/小槽接触。根据连接段的长度，可以推导出基于二级结构的三向结拓扑选择准则。讨论了基于这些规则的实例和预测。
The three-way junctions contained in X-ray structures of folded RNAs have been compiled and analyzed. Three-way junctions with two helices approximately coaxially stacked can be divided into three main families depending on the relative lengths of the segments linking the three Watson-Crick helices. Each family has topological characteristics with some conservation in the non-Watson.-Crick pairs within the linking segments as well as in the types of contacts between the segments and the helices. The most populated family presents tertiary interactions between two helices as well as extensive shallow/minor groove contacts between a linking segment and the third helix. On the basis of the lengths of the linking segments, some guidelines could be deduced for choosing a topology for a three-way junction on the basis of a secondary structure. Examples and prediction based on those rules are discussed.