Parieto-occipital ERP indicators of gut mechanosensation in humans.
Parieto-occipital ERP indicators of gut mechanosensation in humans.
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DOI：
10.1038/s41467-023-39058-4
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发表时间：
2023-06-13
影响因子：
16.6
通讯作者：
Khalsa, Sahib S.
中科院分区：
文献类型：
--
作者：
Mayeli, Ahmad;Al Zoubi, Obada;White, Evan J.;Chappelle, Sheridan;Kuplicki, Rayus;Morton, Alexa;Bruce, Jaimee;Smith, Ryan;Feinstein, Justin S.;Bodurka, Jerzy;Paulus, Martin P.;Khalsa, Sahib S.
由于无法进入人体内部，理解人类肠道-大脑连接的神经过程一直具有挑战性。在这里，我们研究了神经反应胃肠道感觉使用微创mechanosensory探头通过量化大脑，胃，和知觉反应后摄入的振动胶囊。参与者在两种振动条件（正常和增强）下成功感知胶囊刺激，如上述机会准确性分数所证明的。感知准确性显着提高，在增强相对于正常的刺激，这是与更快的刺激检测和减少反应时间的变异性。在中线附近的顶枕电极中，囊刺激诱导迟发神经反应。此外，这些“胃诱发电位”显示强度依赖性的幅度增加，并与感知的准确性显着相关。我们的结果在一个单独的实验中得到了复制，腹部X射线成像将大多数胶囊刺激定位于胃十二指肠段。结合我们先前的观察，贝叶斯模型能够估计肠-脑机械感觉的计算参数，这些发现突出了人类大脑内肠聚焦感觉监测的独特形式，对理解健康和临床人群的肠道感觉和肠-脑相互作用具有重要意义。了解控制人类肠道-大脑连接的神经过程一直具有挑战性。在这里，作者调查的知觉反应和神经相关的胃肠道感觉使用微创mechanosensory探针。
Understanding the neural processes governing the human gut-brain connection has been challenging due to the inaccessibility of the body’s interior. Here, we investigated neural responses to gastrointestinal sensation using a minimally invasive mechanosensory probe by quantifying brain, stomach, and perceptual responses following the ingestion of a vibrating capsule. Participants successfully perceived capsule stimulation under two vibration conditions (normal and enhanced), as evidenced by above chance accuracy scores. Perceptual accuracy improved significantly during the enhanced relative to normal stimulation, which was associated with faster stimulation detection and reduced reaction time variability. Capsule stimulation induced late neural responses in parieto-occipital electrodes near the midline. Moreover, these ‘gastric evoked potentials’ showed intensity-dependent increases in amplitude and were significantly correlated with perceptual accuracy. Our results replicated in a separate experiment, and abdominal X-ray imaging localized most capsule stimulations to the gastroduodenal segments. Combined with our prior observation that a Bayesian model is capable of estimating computational parameters of gut-brain mechanosensation, these findings highlight a unique form of enterically-focused sensory monitoring within the human brain, with implications for understanding gut feelings and gut-brain interactions in healthy and clinical populations. Understanding the neural processes governing the human gut-brain connection has been challenging. Here, the authors investigate the perceptual response and neural correlates of gastrointestinal sensation using a minimally invasive mechanosensory probe.
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影响因子：
2.6
作者：
Bach, Dominik R.
通讯作者：
Bach, Dominik R.
影响因子：
29
作者：
Espay AJ;Aybek S;Carson A;Edwards MJ;Goldstein LH;Hallett M;LaFaver K;LaFrance WC Jr;Lang AE;Nicholson T;Nielsen G;Reuber M;Voon V;Stone J;Morgante F
通讯作者：
Morgante F
影响因子：
3.3
作者：
Drane DL;Fani N;Hallett M;Khalsa SS;Perez DL;Roberts NA
通讯作者：
Roberts NA
影响因子：
2.6
作者：
Holzl, R;Erasmus, LP;Moltner, A
通讯作者：
Moltner, A
影响因子：
29.4
作者：
Aziz, Q;Andersson, JLR;Thompson, DG
通讯作者：
Thompson, DG