Evaluation of Group Homogeneity During Acupuncture Stimulation in fMRI Studies
Evaluation of Group Homogeneity During Acupuncture Stimulation in fMRI Studies
复制标题
功能磁共振成像研究中针刺刺激过程中群体同质性的评估
DOI：
10.1002/jmri.22238
复制
发表时间：
2010-08-01
影响因子：
4.4
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Sun, Jinbo;Qin, Wei;Tian, Jie
目的：为探讨针刺刺激引起的功能磁共振成像（fMRI）信号变化的个体差异程度，材料与方法：对16名受试者进行针刺ST 36和棋盘格刺激。我们计算的平均距离使用β值的广义线性模型（GLM）分析，并采用它来研究组同质性检测outliers.Results：一个更显着的个体差异，在针刺刺激相比，视觉刺激，通过评估的平均距离。从组的结果中，我们发现，在同质组的结果中，激活更显着。结合行为学和功能磁共振成像的结果，得气指数与针刺刺激的平均距离之间没有直接的相关性。结论：未剔除离群值的传统群体结果不足以敏感地检测出真实的针刺效应。建议今后的针灸研究应考虑个体差异。此外，群体分析与个体分析相结合，对于全面了解针灸效应至关重要。
Purpose: To evaluate the extent of individual differences of functional MRI (fMRI) signal changes induced by acupuncture stimulation.Materials and Methods: Acupuncture at ST36 and checkerboard stimulation was applied to 16 subjects. We calculated the mean distance using beta values in a generalized linear model (GLM) analysis and employed it to study the group homogeneity by detecting the outliers.Results: A more significant individual difference was presented in acupuncture stimulation compared with visual stimulation through evaluation of the mean distance. From the group results, we found that the activations were more significant in the homogeneous group results. Combining the behavior and fMRI results, there was no direct correlation between deqi index and mean distance in acupuncture stimulation. The deqi index of the outlier was in the normal range and did not differ significantly from others.Conclusion: Traditional group results without removing outliers were not sensitive enough to detect the real acupuncture effect. We suggest that individual difference should be taken into consideration for future acupuncture studies. Also, group analysis paralleled with individual analysis is critical for a full understanding of acupuncture effects.