Biochemical markers of bone remodeling and bone sialoprotein in ankylosing spondylitis
Biochemical markers of bone remodeling and bone sialoprotein in ankylosing spondylitis
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DOI：
10.1016/s0009-8981(99)00170-9
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发表时间：
1999-11-01
影响因子：
5
通讯作者：
Herrero-Beaumont, G
中科院分区：
文献类型：
--
作者：
Acebes, C;de la Piedra, C;Herrero-Beaumont, G
本研究的目的是测定一组强直性脊柱炎（AS）患者的骨密度（BMD），并研究这些患者骨重建的变化。研究了18例AS患者（16例男性和2例女性），平均年龄44.7岁，范围21-75岁，和18名年龄和性别匹配的健康对照。采用双能X线骨密度仪测定骨密度。研究了骨重建的以下生化标志物：形成-血清前胶原I的氨基和羧基末端前肽（PINP和PICP）;吸收-尿总和游离脱氧吡啶啉和吡啶啉（TDpyr、FDpyr、TPyr和FPyr）、I型胶原的交联氨基末端端肽（NTX）、I型胶原的羧基末端端肽（CTX）和血清骨唾液蛋白（BSP）。并对各指标进行受试者工作特征（ROC）曲线分析。结果表明，AS患者骨量减少，TPyr、FPyr、TDpyr、FDpyr、NTX和BSP升高，而PICP、PINP和CTX无显著性差异。根据ROC曲线的结果，FDpyr、FPyr和TPyr在患者和对照之间显示出最高的区分度。TPyr/TDpyr在AS组高于对照组。我们发现骨质减少，与正常的形成和骨吸收的AS显着增加。FDpyr、FPyr和TPyr似乎是研究这种病理学中骨吸收改变的最佳敏感性，尽管NTX、TDpyr和BSP也显示出显著差异。与对照组相比，AS中TPyr/TDpyr比率的升高表明，在AS中，在不同于骨的组织中存在I型胶原降解。(C)1999 Elsevier Science B. V.保留所有权利。
The aim of this work was to determine bone mineral density (BMD) in a group of patients with ankylosing spondylitis (AS) and to study alterations in bone remodeling in these patients. Eighteen patients (16 males and two females) with AS, mean age 44.7, range 21-75, and 18 age- and sex-matched healthy controls were studied. BMD was evaluated by dual energy X-ray absorptiometry. The following biochemical markers of bone remodeling were studied: formation - serum amino and carboxyterminal propeptides of procollagen I (PINP and PICP); resorption - urinary total and free deoxypyridinoline and pyridinoline (TDpyr, FDpyr, TPyr and FPyr), crosslinked aminoterminal telopeptides of collagen I (NTX), carboxyterminal telopeptide of collagen I (CTX) and serum bone sialoprotein (BSP). Receiver operatings characteristic (ROC) curves of markers were also performed. We found a decrease of bone mass and an increase in TPyr, FPyr, TDpyr, FDpyr, NTX and BSP in AS, but no significant differences were found in PICP, PINP and CTX. FDpyr, FPyr and TPyr showed the highest discrimination between patients and controls according to the results of the ROC curves. TPyr/TDpyr was higher in AS than in controls. We found osteopenia, with a normal formation and a significant increase in bone resorption in AS. FDpyr, FPyr and TPyr seem to present the best sensitivity for the study of alterations of bone resorption in this pathology, although NTX, TDpyr and BSP also show significant differences. The elevation in the ratio TPyr/TDpyr in AS compared to controls indicates that in AS there is a type I-collagen degradation in tissues different from bone. (C) 1999 Elsevier Science B.V. All rights reserved.